First trimester placental growth factor in maternal blood and placenta related disorders.

J Matern Fetal Neonatal Med

El Bosque Research Group of Maternal Fetal Medicine and Gynecology, Universidad El Bosque, Ecodiagnóstico El Bosque S.A.S, Los Cobos Medical Center, Bogotá, Colombia.

Published: December 2022

Objective: To describe and compare the placental growth factor levels at first trimester in patients that developed preeclampsia, gestational hypertension, IUGR and in those patients without impaired placentation diseases.

Methods: Observational study based on a prospective cohort of 422 pregnant women. PlGF values were compared between the different groups (preeclampsia, intrauterine growth restriction (IUGR), gestational hypertension or normal group-patients without impaired placentation diseases).

Results: The 85.3% ( = 360, 95% CI = 81.9-88.7) had a normal pregnancy, 7.6% ( = 32, 95% CI = 5.1-10.1) had preeclampsia, 3.8% ( = 16, 95% CI = 2.0-5.6) had IUGR and 3.3% ( = 14, 95% CI = 1.6-5.0) had gestational hypertension. The median level of PlGF for preeclampsia (0.76) and IUGR (0.75) were lower than gestational hypertension (0.82) and normal group (1.02). The groups of preeclampsia >34 weeks (0.76), preeclampsia <37 weeks (0.73), and preeclampsia ≥37 weeks (0.77), were significantly lower than the normal group. The sensitivity and specificity of PlGF for impaired placentation diseases is 65% and 64.9%, respectively.

Conclusion: It was found in this study that PlGF has significantly lower levels in gestational hypertension than normal pregnancies, in concordance with the other impaired placentation diseases. Additionally, a better comparison of the PlGF values was obtained when separating early onset of preeclampsia <37 weeks and late-onset of preeclampsia 37≥ weeks of gestations.

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Source
http://dx.doi.org/10.1080/14767058.2021.1960966DOI Listing

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