Two new bioactive trisubstituted furanones, named pinofuranoxins A and B ( and ), were isolated from , a worldwide conifer pathogen causing severe disease. Pinofuranoxins A and B were characterized essentially by NMR and HRESIMS spectra, and their relative and absolute configurations were assigned by NOESY experiments and computational analyses of electronic circular dichroism spectra. They induced necrotic lesions on L., L., and L. Compound completely inhibited the growth of and , while showed antioomycetes activity against . In the assay both toxins showed activity inducing larval mortality.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8477388 | PMC |
| http://dx.doi.org/10.1021/acs.jnatprod.1c00365 | DOI Listing |
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