AI Article Synopsis
- Breast cancer patients receiving radiotherapy experience increased fatigue during treatment, particularly in the first three and last two weeks.
- Fatigue levels tend to return to baseline within 1-3 months after completing radiotherapy, but certain groups (like younger patients and those with past chemotherapy) report higher fatigue levels.
- The study highlights the need for more research to address fatigue in mastectomy patients, especially those who have also undergone chemotherapy and younger individuals.
Article Abstract
Purpose: Breast cancer patients receiving adjuvant radiotherapy (RT) benefit from local control. However, RT can give rise to increased fatigue, lowering quality of life. The aim of this study was to prospectively identify trends and risk factors in patient-reported fatigue associated with breast RT.
Material And Methods: Patients were assessed using the Edmonton Symptom Assessment Scale (ESAS) before, once per week during RT, up to 6 weeks after RT completion, and 1-3 months post RT. Patients were included in the analysis if the ESAS was completed before, at least once during, and at least once after RT.
Results: A total of 651 patients were included. Fatigue scores increased significantly during weeks 1-3 (p < 0.001) and weeks 5-6 (p < 0.0001) during RT compared to baseline. After RT completion, fatigue scores did not change significantly compared to baseline. Mastectomy patients who received previous chemotherapy experienced significantly more fatigue compared to mastectomy patients without previous chemotherapy (p = 0.0002). Patients less than 50 (p = 0.002), 50-59 (p = 0.007), or 60-69 (p = 0.048) years of age at RT start were more likely to have higher proportions of moderate or severe fatigue compared to patients ≥ 70 years of age.
Conclusions: Fatigue associated with breast irradiation increased up to 6 weeks during RT and returned to near baseline scores at 1-3 months post treatment. Given that fatigue was significant in mastectomy patients, further research is needed to reduce fatigue among this cohort, especially those who have received previous chemotherapy and younger patients who are receiving breast RT.
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| http://dx.doi.org/10.1007/s00520-021-06521-1 | DOI Listing |
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