Relations of heart-type and brain-type fatty acid-binding proteins with postoperative cognitive dysfunction in elderly patients undergoing spinal surgery.

Minbo Jiang Yang Li Lei Cao Jiwei Tian Deguo Wang

Rev Assoc Med Bras (1992)

Central Hospital of Songjiang District, Department of Orthopedics - Shanghai, China.

Published: March 2021

The study investigates the connection between two proteins, H-FABP and B-FABP, and the risk of postoperative cognitive dysfunction (POCD) in elderly spinal surgery patients.
A total of 125 participants were split into groups based on whether they experienced POCD after surgery, with evaluations of protein levels before and after the procedure.
Results showed that patients with POCD had higher levels of H-FABP and B-FABP post-surgery compared to their pre-surgery levels and also compared to patients without POCD, indicating a link between these proteins and cognitive dysfunction.

Objective: The aim of this study is to analyze the relations of heart-type fatty acid-binding protein (H-FABP) and brain-type fatty acid-binding protein (B-FABP) with postoperative cognitive dysfunction (POCD) in elderly patients undergoing spinal surgery.

Methods: One hundred and twenty-five patients who underwent spinal surgery were enrolled in this study. According to whether patients had POCD within 5 days after surgery, the participants were divided into POCD group and non-POCD group. Before surgery and 6 h after surgery, the serum H-FABP and B-FABP contents were detected.

Results: There were 33 (26.4%) patients in POCD group, and 92 (73.60%) patients in non-POCD group. After surgery, the serum H-FABP and B-FABP contents in POCD group were significantly higher than those before surgery, respectively (p<0.05), and those in non-POCD group were significantly lower than those before surgery, respectively (p<0.05). After surgery, the serum H-FABP and B-FABP contents in POCD group were significantly higher than those in non-POCD group, respectively (p<0.05).

Conclusion: The serum H-FABP and B-FABP contents are positively related to the occurrence of POCD in elderly patients undergoing spinal surgery.

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http://dx.doi.org/10.1590/1806-9282.20200784	DOI Listing

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