AI Article Synopsis
- - Genetic recombination significantly influences the evolution of positive sense RNA viruses when multiple viruses infect the same cell, leading to new genetic combinations.
- - The main method of recombination involves the viral polymerase, which creates chimeric genomes by switching DNA templates during replication, though there are indications of recombination that doesn't rely on this polymerase activity.
- - It's unclear how often these non-replicative recombination events occur, how they differ from polymerase-driven recombination, or if they involve non-virus-specific sequences, suggesting a broader mechanism beyond just RNA viruses.
Article Abstract
Genetic recombination is a major force driving the evolution of some species of positive sense RNA viruses. Recombination events occur when at least two viruses simultaneously infect the same cell, thereby giving rise to new genomes comprised of genetic sequences originating from the parental genomes. The main mechanism by which recombination occurs involves the viral polymerase that generates a chimera as it switches templates during viral replication. Various experimental systems have alluded to the existence of recombination events that are independent of viral polymerase activity. The origins and the frequency of such events remain to be elucidated to this day. Furthermore, it is not known whether non-replicative recombination yields products that are different from recombinants generated by the viral polymerase. If this is the case, then non-replicative recombination may play a unique role in the evolution of positive sense RNA viruses. Finally, the sparse data available suggest that non-replicative recombination does not necessarily involve only virus-specific sequences. It is thus possible that the non-replicative recombination observed in virus-focused studies may in fact reveal a more generalized mechanism that is non-specific to virus RNAs.
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| http://dx.doi.org/10.1684/vir.2021.0914 | DOI Listing |
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