Group A streptococcus (GAS) pharyngitis is a common clinical infection with significant morbidity but remains understudied. We sought to assess the rates of testing and incidence of GAS pharyngitis in Calgary, Alberta based on age and sex. A total of 1,074,154 tests were analyzed (58.8% female, mean age 24.8 years) of which 16.6% were positive. Age-standardized testing and positivity was greatest in the 5-14 years age group and lowest in persons over 75 years. Females had greater rates of testing and positivity throughout. Testing rates (incidence rate ratios: 1.40, 95% CI: 1.39-1.41) and case rates (incidence rate ratios: 1.36, 95% CI: 1.33-1.39) increased over time. Future studies should focus on evaluating disparities in testing and treatment outcomes to optimize the approach to this infection.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.2217/fmb-2021-0077 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Impact of the SARS-CoV-2 Pandemic on the Epidemiology of : A Five-Year Retrospective Study.
Microorganisms
November 2024
Microbiology Department, Hospital Universitario 12 de Octubre, Avda. Córdoba s/n, 28041 Madrid, Spain.
The SARS-CoV-2 pandemic significantly affected the epidemiology of , a pathogen associated with various clinical presentations such as pharyngitis, scarlet fever, and invasive diseases. This study analyzed the incidence and characteristics of infections between 2018 and 2023, examining 915 cases categorized as either respiratory or non-respiratory. Respiratory infections predominantly affected children, accounting for 76% of cases, with a median age of 5 [3, 8] years, while non-respiratory infections were more common in adults, with a median age of 46.
View Article and Find Full Text PDFExploring Peripheral and Cardiac Immune Responses in a Pneumosepsis Mouse Model with Group A Streptococcus.
Am J Respir Cell Mol Biol
January 2025
Rostock University Medical Center, Institute of Medical Microbiology, Virology and Hygiene, Rostock, Germany.
(Group A Streptococcus, GAS) is a human pathogen that causes local and systemic infections of the skin and mucous membranes. However, GAS is also found asymptomatically in the nasopharynx of infants. GAS infections, including pharyngitis and invasive pneumosepsis, pose significant public health concerns.
View Article and Find Full Text PDFImplementation of molecular diagnostic testing for group A streptococcal pharyngitis: considerations and challenges with a focus on point-of-care environments.
Expert Rev Mol Diagn
December 2024
Scientific Affairs, Cepheid, Sunnyvale, CA, USA.
Introduction: Rapid and accurate detection of group A (GAS) pharyngitis allows for timely initiation of appropriate antibiotic treatment. This is important to prevent empiric antibiotic overuse while simultaneously lowering the risk of post-infection sequelae. Timely treatment may also reduce forward transmission, which could prevent cases of devastating invasive infections.
View Article and Find Full Text PDFAn Autopsy Case of Rapidly Fulminant Group A Streptococcus Infection in a Previously Healthy 67-Year-Old Woman.
Cureus
November 2024
Department of Diagnostic Pathology (DDP) and Research Center of Diagnostic Pathology (RC-DiP), Gifu Municipal Hospital, Gifu, JPN.
, also known as group A (GAS), is responsible for various conditions, such as pharyngitis, tonsillitis, necrotizing fasciitis, and streptococcal toxic shock syndrome (STSS). STSS, a rapidly progressing infection involving shock and multi-organ failure, was first reported in Japan in 1992, and since then, the number of cases has been steadily increasing. We herein report an autopsy case of STSS that resulted in sudden death.
View Article and Find Full Text PDFDetermination of the upper limit of normal for serum anti-streptolysin-O titre in primary school children in Southern Nigeria; A model for other low resource settings.
Int J Cardiol Cardiovasc Risk Prev
June 2024
Department of Child Health, University of Benin Teaching Hospital, PMB 1111, Benin City, Nigeria.
The prevention and treatment of Rheumatic Heart disease is hinged on antibiotic administration in children with Group A (GAS) pharyngitis and Acute Rheumatic Fever (ARF). The Upper Limit of Normal (ULN) for serum Anti-streptolysin O titre (ASOT) has been employed as proof of antecedent GAS pharyngitis to fulfil the Jones' criteria for diagnosis of ARF. This value has not been generated among West African children.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!