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| http://dx.doi.org/10.32481/djph.2020.11.011 | DOI Listing |
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Systemic ketamine toxicity following dermal application of a compounded pain cream.
Am J Emerg Med
December 2024
Cook County Health, Chicago, IL, USA.
Ketamine is an NMDA receptor antagonist commonly used as a dissociative anesthetic and analgesic. Though it is conventionally administered via the intravenous, intramuscular, or intranasal route, use as a compounded analgesic cream is becoming increasingly common. This is a case report of a 61-year-old man who was detained by the police for erratic driving.
View Article and Find Full Text PDFUrinary excretion profiles of the orexin receptor antagonist suvorexant and its metabolites.
Forensic Toxicol
December 2024
Forensic Science Laboratory, Osaka Prefectural Police Head Quarters, 1-3-18, Hommachi, Chuo-Ku, Osaka, 541-0053, Japan.
Purpose: Suvorexant is an orexin receptor antagonist used in the treatment of insomnia. In this study, we investigated the urinary excretion profiles of suvorexant and its major metabolites, including conjugates, to obtain fundamental information for proving exposure to suvorexant in criminal cases.
Methods: Urine specimens were collected from three subjects for maximum 168 h after a single oral ingestion of suvorexant (10 mg), and suvorexant and its metabolites in urine were determined using liquid chromatography-tandem mass spectrometry with a C18 semi-micro column.
Synthesis of N-Doped Graphene Quantum Dots from Cellulose and Construction of a Fluorescent Probe for 6-Mercaptopurin Quantitative Detection.
Materials (Basel)
November 2024
School of Resources, Environment and Materials, Guangxi University, Nanning 530004, China.
With cellulose as the precursor and ethylenediamine as the N source, N-doped graphene quantum dots (N-GQDs) were synthesized by a simple and feasible one-pot hydrothermal method. The whole process did noSchemet need a strong acid or strong base and avoided interference from inorganic salt residues. The whole process lasted only 3 h and avoided any complex postprocessing.
View Article and Find Full Text PDFPolycyclic Aromatic Hydrocarbons Mediate the Association between Tobacco Smoking and Alcohol Use Disorder.
Yonsei Med J
December 2024
Department of Preventive Medicine, Yonsei University College of Medicine, Seoul, Korea.
Article Synopsis
- - The study explored the link between smoking and alcohol use disorder in 968 male firefighters, focusing on the role of polycyclic aromatic hydrocarbons (PAHs) found in tobacco smoke as potential mediators in this relationship.
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Rational construction of porous cobalt nanoparticle integrated nitrogen doped hollow carbon nanostructures for peptide agonist exendin-4 biosensing.
Biosens Bioelectron
February 2025
New Technologies - Research Center, University of West Bohemia, Plzen, 30100, Czech Republic. Electronic address:
In this study, we designed a point-of-care (POC) testing electrochemical biosensor using an integrated biosensing assay based on hollow-like nitrogen-doped carbon nanostructures combined with cobalt nanoparticles (Co@HNCNs, CoO@HNCNs, and CoP@HNCNs). These are functionalized with Anti-Exendin-4 Antibodies (Anti-Ex-4-Abs) and Bovine Serum Albumin (BSA) to create sensitive probes (Co@HNCNs/Anti-Ex-4-Abs/BSA, CoO@HNCNs/Anti-Ex-4-Abs/BSA, and CoP@HNCNs/Anti-Ex-4-Abs/BSA) for the ultrasensitive detection of exendin-4 (Ex-4), a peptide agonist used in the treatment of type 2 diabetes mellitus (T2DM). Among the cobalt-based carbon nanostructures, the CoO@HNCNs/Anti-Ex-4-Abs/BSA nanoprobe demonstrated superior ability to specifically recognize Ex-4.
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