This report highlights azathioprine-induced severe myelosuppression in the patient with NUDT15 minor variant. This case report is particularly instructive because several typical symptoms are the clues to this critical adverse drug reaction.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8385330 | PMC |
http://dx.doi.org/10.1002/ccr3.4696 | DOI Listing |
J Am Anim Hosp Assoc
May 2024
From Foxboro Animal Hospital, Foxboro, MA.
Only one report on the successful use of filgrastim (granulocyte colony-stimulating factor) in cats for severe neutropenia following azathioprine toxicity exists. Here, we report on a case in which a cat was prescribed methimazole but the medication was filled incorrectly with azathioprine tablets and the prescription label indicated a methimazole dosing regimen that was administered for three days before recognition of the error. On presentation, the cat's physical examinations were consistent with previous examinations before ingestion of azathioprine.
View Article and Find Full Text PDFDrug Ther Bull
March 2024
Liver and Gastroenterology Unit, ASST Santi Paolo e Carlo, Milan, Italy.
Cutis
May 2023
Yale School of Medicine, New Haven, Connecticut. Drs. Leventhal and Vesely are from the Department of Dermatology.
The diagnosis of scabies can be difficult when the infection presents as erythroderma. Crusted scabies is a severe form of scabies caused by cutaneous ectoparasitic infection by the mite Sarcoptes scabiei var hominis. Crusted scabies most commonly occurs in patients with underlying immunosuppression from acquired infection or subsequent to solid organ or bone marrow transplantation.
View Article and Find Full Text PDFFront Pharmacol
May 2023
Department of Pharmacy, Affiliated Hospital of Zunyi Medical University, Zunyi, China.
Br J Clin Pharmacol
August 2023
Unité de Pharmacogénétique, Service de Biochimie, Hôpital européen Georges Pompidou, AP-HP.Centre, Université Paris Cité, Paris, France.
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