Antipyretic activity of (Rottl.) leaves extract along with phytoconstituent's binding affinity to COX-1, COX-2, and mPGES-1 receptors: and approaches.

(Rottl.) (Family: Fabaceae) is well known for its numerous medicinal values against several human disorders including fever, senile pruritis, diarrhea, tuberculosis, tonic disorder, diabetes, etc. The current study is intended to investigate the antipyretic activity of the methanol extract of leaves (MECD) and its carbon-tetrachloride (CTCD) and butanol fraction (BTCD). Besides, molecular docking and ADME/T profiling of the selective identified bioactive compounds of has been also studied to validate the experimental outcomes and establish a better insight into the possible receptor-ligand interaction affinity. antipyretic activity of MECD, CTCD and BTCD were evaluated by employing yeast induced pyrexia technique in mice model and analysis of the identified compounds of has been implemented using PyRx autodock vina, Discovery Studio 2020, UCSF Chimera software and ADME/T online tools. MECD and BTCD unveiled significant antipyretic activity in dose dependent manner whereas, CTCD failed to exhibit significant antipyretic activity. Comparing to other test sample, MECD (400 mg/kg; b.w) ( < 0.001) displayed maximum inhibition of pyrexia. In molecular docking approach, docking score between -6.60 to -10.20 kcal/mol have been revealed. Besides, in ADME/T analysis, no compound violated the lipiniski's 5 rules and displayed any toxicity. Biological and computational approaches ascertain the ethno-botanical use of as a good agent against pyrexia and the compounds of are primarily proved as safe. Hereafter, further analysis is suggested to validate this research.