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Dengue and human health: A global scenario of its occurrence, diagnosis and therapeutics. | LitMetric

Dengue and human health: A global scenario of its occurrence, diagnosis and therapeutics.

Saudi J Biol Sci

Department of Biological Sciences, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia.

Published: September 2021

AI Article Synopsis

  • Dengue is a rapidly spreading viral disease transmitted by the Aedes aegypti mosquito, leading to serious public health issues and high mortality rates, particularly in tropical and subtropical regions.
  • Caused by an RNA virus from the Flaviviridae family, there are five identified serotypes (DENV-1 to DENV-5) that pose significant health and economic challenges worldwide.
  • The review discusses the virus's origins, detection methods, structure, classifications, replication processes, and current challenges regarding treatment and vaccine trials.

Article Abstract

Dengue is one of the highest and rapidly spreading vector-borne viral diseases with high mortality rates. The infection causes acute febrile illness, a major public health concern in the tropics and subtropics globally. The disease is caused by an RNA virus that belongs to the Flaviviridae family. The virus is transferred to humans by the mosquito vector called Aedvrves aegypti, which is the cause of new prevalent sicknesses worldwide. These vector-borne viral diseases spread very fast and pose public health and economic challenges that deemed various prevention and control techniques. The genus consists of five different types of viruses starting from DENV-1 to DENV-5. Thus, the present review focuses on the origin of the virus, how the Dengue virus can be detected, infection, the morphology of the virus, its classifications as proposed by ICTV, the replication and genome of the dengue virus, translation, receptor binding, and some vaccine trial volunteers. In addition, it highlights the current challenges and limitations of effective dengue treatment.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8381008PMC
http://dx.doi.org/10.1016/j.sjbs.2021.05.023DOI Listing

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