AI Article Synopsis
- A study in South Korea analyzed pediatric invasive pneumococcal diseases (IPDs) from 2014 to 2019 to examine changes in serotype distribution following the introduction of pneumococcal vaccines.
- Vaccine serotypes (VTs) made up a small portion of the isolates (16.1%), while a majority (82.1%) were nonvaccine serotypes (NVTs), with serotype 10A being the most common and significantly increasing over the study period.
- Most serotype 10A isolates were identified as multidrug-resistant ST11189, highlighting a concerning trend in antibiotic resistance among these infections.
Article Abstract
Replacement with nonvaccine serotypes (NVTs) among invasive pneumococcal diseases (IPDs) after the introduction of extended-valency pneumococcal conjugate vaccines varies in predominant serotypes across countries. This study analyzed changes in serotype distribution through serotyping, multilocus sequence typing, and antimicrobial susceptibility testing of 168 pediatric IPD isolates obtained from a multihospital-based surveillance system during 2014-2019 in South Korea. Vaccine serotypes (VTs) accounted for 16.1% (19A, 10.1%; 6A, 1.8%; and 19F 1.8%), 82.1% were NVTs (10A, 23.8%; 15A, 8.3%; 12F, 6.5%; 15C, 6.5%; and 15B, 6.0%), and three (1.8%) were nontypeable. Serotype 10A was the most common serotype, with a significant increase from 11.5% in 2014 to 33.3% in 2019 (p < 0.05 for the trend). Other NVTs decreased from 70.4% to 41.7% between 2015 and 2019, most notably in serotype 12F (from 14.8% to 0%). Almost all (95.0%) serotype 10A isolates were ST11189, which were multidrug resistant.
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| http://dx.doi.org/10.1016/j.vaccine.2021.08.072 | DOI Listing |
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