A retrospective study of 58 thyroid patients undergoing eyelid surgery for thyroid related lid malposition is reported. A treatment strategy is suggested, based on the results of this experience. The following points are stressed: (1) The importance of recognising and relieving the inferior rectus tethering component of upper lid retraction when present. (2) The usefulness of a scleral graft in lower lid retractor recession. (3) The inadequacy of lateral tarsorrhaphy in relieving lid retraction but its value in camouflage.
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http://dx.doi.org/10.1038/eye.1987.94 | DOI Listing |
Ophthalmic Plast Reconstr Surg
December 2024
Department of Ophthalmology and Visual Sciences, Montefiore Medical Center, Albert Einstein College of Medicine.
Purpose: Thyroid eye disease-related retraction and strabismus treatment is complicated by the activity level of the disease. Botulinum toxin injection can provide relief of symptoms in lieu of, or while waiting for surgery, radiation, or alternative medications. This study reviews techniques, outcomes, and effectiveness of botulinum toxin usage in thyroid eye disease.
View Article and Find Full Text PDFSultan Qaboos Univ Med J
November 2024
Department of Medicine, Sultan Qaboos University, Muscat, Oman.
Thyroid eye disease (TED) is the most common symptoms of Graves' disease. This condition commonly manifests bilaterally and symmetrically. The most prominent symptoms are lid retraction, exophthalmos and diplopia.
View Article and Find Full Text PDFBiochemistry
December 2024
Department of Chemistry, Indian Institute of Technology Kharagpur, Kharagpur 721302, West Bengal, India.
Human iodotyrosine deiodinase (hIYD) catalyzes the reductive deiodination of iodotyrosine using a flavin mononucleotide cofactor to maintain the iodine concentration in the body. Mutations in the hIYD gene are linked to human hypothyroidism, emphasizing its role in thyroid function regulation. The present work employs microsecond-scale molecular dynamics simulations and quantum chemical calculations to elucidate the conformational dynamics and reactivity in the active site at various stages of hIYD enzymatic cycle.
View Article and Find Full Text PDFJ Craniofac Surg
November 2024
Department of Ophthalmology, Korea University College of Medicine, Seoul, Korea.
Objective: The purpose of this experiment was to evaluate the functional and histologic changes in the upper eyelid muscles after injection of triamcinolone acetonide (TA) alone or TA combined with botulinum toxin A (Botox or BTXA) in the cynomolgus monkey model.
Methods: Twenty eyes of 10 cynomolgus monkeys were divided into 4 groups: 3 experimental groups (1, 2, and 3) and the control group (group 4) based on the injection type. In group 1, 0.
Am J Ophthalmol
January 2025
From the Stein Eye Institute and Department of Ophthalmology, University of California (W.-Y.L., J.L.D.), Los Angeles, California, USA; Department of Neurology, University of California (J.L.D.), Los Angeles, California, USA; Bioengineering Department, University of California (J.L.D.), Los Angeles, California, USA; Neuroscience Interdepartmental Program, University of California (J.L.D.), Los Angeles, California, USA. Electronic address:
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