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Borrelia burgdorferi sensu lato inhibits CIITA transcription through pSTAT3 activation and enhanced SOCS1 and SOCS3 expression leading to limited IFN-γ production.
Ticks Tick Borne Dis
January 2025
Department of Internal Medicine and Radboud Community for Infectious diseases (RCI), Radboud University Medical Center, Nijmegen, the Netherlands; Department of Medical Genetics, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania. Electronic address:
Interferons (IFNs) are important signaling molecules in the human immune response against micro-organisms. Throughout initial Borrelia burgdorferi sensu lato (B. burgdorferi s.
View Article and Find Full Text PDFFocus on brown dog tick-transmitted Rocky Mountain spotted fever in dogs and people: shared threats and solutions.
J Am Vet Med Assoc
January 2025
3Red de Biología y Conservación de Vertebrados, Instituto de Ecología AC, Veracruz, México.
Rocky Mountain spotted fever (RMSF) kills people and dogs in rural communities throughout the Americas and in urban epidemics in Brazil and Mexico. The companion Currents in One Health by Foley et al, AJVR , March 2025, addresses the urban ecology of this devastating disease across the Americas. Cases acquired from Dermacentor spp ticks are sylvatic and sporadic, in contrast with peridomestic cases from Rhipicephalus sanguineus sensu lato, which relies on dogs as hosts.
View Article and Find Full Text PDFCo-infections of rickettsiales in clinically healthy, Leishmania infantum seropositive and seronegative dogs: a systematic literature review and new findings from Southern Italy.
Parasitol Res
January 2025
Department of Veterinary Medicine, University of Bari, Valenzano, Italy.
Canine leishmaniosis (CanL), caused by Leishmania infantum, is a widespread vector-borne disease. In Italy, an endemic region for CanL, overlapping transmission of L. infantum and tick-borne pathogens (TBPs) like Anaplasma phagocytophilum and Ehrlichia canis is increasingly reported.
View Article and Find Full Text PDFhsa-miR-548d-3p: a potential microRNA to target nucleocapsid and/or capsid genes in multiple members of the Flaviviridae family.
Front Bioinform
January 2025
Hakim's Lab, Department of Biology, School of STEM, Diné College, Tuba City, AZ, United States.
Introduction: Flaviviridae comprise a group of enveloped, positive-stranded RNA viruses that are mainly transmitted through either mosquitoes or tick bites and/or contaminated blood, blood products, or other body secretions. These viruses cause diseases ranging from mild to severe and are considered important human pathogens. MicroRNAs (miRNAs) are non-coding molecules involved in growth, development, cell proliferation, protein synthesis, apoptosis, and pathogenesis.
View Article and Find Full Text PDFVisualization of Nucleic Acids in Microand Nanometer-Scale Biological Objects Using Analytical Electron Microscopy.
Acta Naturae
January 2024
Lomonosov Moscow State University, Faculty of Biology, Moscow, 119234 Russian Federation.
Analytical electron microscopy techniques, including energy-dispersive X-ray spectroscopy (EDX) and electron energy-loss spectroscopy (EELS), are employed in materials science and biology to visualize and chemically map diverse elements. This review presents cases of successful identification of nucleic acids in cells and in DNA- and RNA-containing viruses that use the chemical element phosphorus as a marker.
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