This viewpoint article describes an effective model for creating and sustaining an affinity group for undergraduate and graduate students from racial and ethnic backgrounds historically underrepresented in the American Speech-Language-Hearing Association who are enrolled in communication sciences and disorders (CSD) programs at predominantly White institutions (PWIs). The Speech-Language Therapy & Audiology Minority Program (STAMP) at Nazareth College is an affinity group and mentorship program for undergraduate and graduate students, CSD program alumni, and area professionals who identify as minorities. Affinity groups have been shown to increase the sense of belonging of minority students at PWIs. At Nazareth College, we have observed this as students who participate in STAMP have reported that the program contributes to their feeling of belonging in the CSD department and at the institution and provides them with a safe place where they can share and discuss their experiences as minorities at a PWI. Additionally, our students have reported that participating in this affinity group supports their academic and clinical success and helps them manage their stress. By sharing our model for creating an affinity group for underrepresented CSD students at a PWI, we hope to encourage the establishment and support of groups like STAMP in CSD programs across the country. Considerations for departments considering starting their own affinity groups are discussed. STAMP, and other affinity groups, have the potential to grow by facilitating constructive discussion and collective action toward issues that significantly impact students from racial and ethnic minority backgrounds.
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http://dx.doi.org/10.1044/2021_AJSLP-20-00342 | DOI Listing |
J Phys Chem B
January 2025
Department of Chemistry and Biochemistry, Brigham Young University, Provo, Utah 84602, United States.
Macrocyclization or stapling is an important strategy for increasing the conformational stability and target-binding affinity of peptides and proteins, especially in therapeutic contexts. Atomistic simulations of such stapled peptides and proteins could help rationalize existing experimental data and provide predictive tools for the design of new stapled peptides and proteins. Standard approaches exist for incorporating nonstandard amino acids and functional groups into the force fields required for MD simulations and have been used in the context of stapling for more than a decade.
View Article and Find Full Text PDFAnal Chem
January 2025
Guangdong Provincial Key Laboratory of Food Quality and Safety, South China Agricultural University, Guangzhou 510642, China.
The rapid, sensitive, and accurate detection of paralytic shellfish toxins (PSTs), such as saxitoxin (STX), is critical for protecting human health due to the frequent occurrence of toxic red tides. In this work, to address the low affinity of traditional mouse monoclonal antibodies (m-mAbs), rabbit monoclonal antibodies (r-mAbs) against STX were produced by a single B-cell sorting culture and a cross-selection strategy. The r-mAbs showed 100-fold improvement in sensitivity (IC = 0.
View Article and Find Full Text PDFNeurochem Res
January 2025
Department of Pharmacology, Central University of Punjab, Ghudda, Bhatinda, Punjab, 151401, India.
Antipsychotic medications are used to treat a psychological condition called 'Schizophrenia'. However, its long-term administration causes irregular involuntary motor movements, targeting the orofacial regions. Glycyrrhizic acid (GA) is a naturally occurring triterpene saponin glycoside obtained from the roots of the Glycyrrhiza glabra (liquorice) plant and well known for its antioxidant, antiapoptotic and neuroprotective abilities.
View Article and Find Full Text PDFCardiovasc Drugs Ther
January 2025
Department of Cardiothoracic Surgery, Affiliated Hospital of Nantong University, Nantong, 226000, Jiangsu, China.
Purpose: Cardiac inflammation is a basic pathological process of diabetic cardiomyopathy (DCM). Inflammatory response is closely related to pyroptosis, which is a recently identified programmed cell death type. Curcumin (CUR) is a polyphenol extracted from turmeric and has been reported to be crucial in alleviating pyroptosis in DCM.
View Article and Find Full Text PDFAngew Chem Int Ed Engl
January 2025
Texas A&M University, Department of Chemistry, Texas A&M University, 77842, College Station, UNITED STATES OF AMERICA.
Lewis acids play a central role in a large variety of chemical transformations. The reactivity of the strongest Lewis acids is typically studied in the context of affinity towards hard bases, such as fluoride or oxygenous species. Carbocations can be viewed as soft Lewis acids, possessing significant affinity for softer bases, such as hydride.
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