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http://dx.doi.org/10.1111/j.1365-2230.1987.tb02512.x | DOI Listing |
Front Allergy
January 2025
Division of Allergy and Clinical Immunology, School of Medicine, University of Virginia, Charlottesville, VA, United States.
Front Physiol
January 2025
Walther Straub Institute of Pharmacology and Toxicology, Faculty of Medicine, Ludwig-Maximilians-University, Munich, Germany.
Two-pore channels (TPCs) are adenine nucleotide and phosphoinositide regulated cation channels. NAADP activates and ATP blocks TPCs, while the endolysosomal phosphoinositide PI(3,5)P activates TPCs. TPCs are ubiquitously expressed including expression in the innate as well as the adaptive immune system.
View Article and Find Full Text PDFBackground: Myasthenia gravis (MG) and idiopathic inflammatory myopathies (IIM) are autoimmune disorders that can co-occur, complicating diagnosis and treatment. The molecular mechanisms underlying this comorbidity are not well understood.
Objective: This study aims to identify common differentially expressed genes (co-DEGs) between MG and IIM to elucidate shared pathogenic pathways and potential therapeutic targets.
J Allergy Clin Immunol Pract
January 2025
Wilford Hall Ambulatory Surgical Center, 1100 Wilford Hall Loop, Joint Base San Antonio - Lackland, TX 78236. Electronic address:
Pharmaceuticals (Basel)
December 2024
Post Graduate Program in Structural and Functional Biology, Paulista School of Medicine (UNIFESP-EPM), Federal University of São Paulo, São Paulo 04023-062, SP, Brazil.
is traditionally known for its medicinal properties. Objectives: Here, we investigated the effects of crude extract (CE) and ethyl acetate fraction (EAF) obtained from leaves on the ascitic (EA) and solid (ES) forms of Ehrlich tumors. : Induced and uninduced BALB/c mice were treated intramuscularly, for 7 or 14 days, with saline solution or CE and EAF, both at a 10% concentration, based on in vitro cytotoxicity assessment.
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