AI Article Synopsis
- - Fifteen new isopimarane-type diterpenes (taichunins E-S) and one new 20-isopimarane (taichunin T) were isolated from a specific strain (IBT 19404), alongside four known compounds.
- - The structures of these new compounds were identified using NMR and mass spectroscopy, with their configurations analyzed through NOESY and TDDFT calculations of ECD spectra.
- - Taichunins G, K, and N showed complete inhibition of RANKL-induced osteoclast formation in RAW264 cells at 5 μM, and one compound exhibited 92% inhibition at just 0.2 μM.
Article Abstract
Fifteen new isopimarane-type diterpenes, taichunins E-S (-), and a new 20--isopimarane, taichunin T (), together with four known compounds were isolated from (IBT 19404). The structures of these new compounds were determined by NMR and mass spectroscopy, and their absolute configurations were analyzed by NOESY and TDDFT calculations of ECD spectra. Taichunins G, K, and N (, , and ) completely inhibited the receptor activator of nuclear factor-κB ligand (RANKL)-induced formation of multinuclear osteoclasts in RAW264 cells at 5 μM, with showing 92% inhibition at a concentration of 0.2 μM.
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| http://dx.doi.org/10.1021/acs.jnatprod.1c00486 | DOI Listing |
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