A one-step cascade reaction of tryptamine-derived isocyanides with generated nitrile oxides for the synthesis of fused spiroindolines was described. The desired products could be efficiently synthesized in moderate to good yields (42-87%). The protocol features mild conditions, wide substrate scope, and high efficiency.
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| http://dx.doi.org/10.1021/acs.joc.1c01054 | DOI Listing |
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