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Probing the interaction of mannose-binding lectin with healthy and sickle cell anemia red blood cells and its role in cellular biomechanics.
Int J Biol Macromol
January 2025
Departmento de Biofísica e Radiobiologia, Universidade Federal de Pernambuco, Recife, Pernambuco 50670-901, Brazil. Electronic address:
Mannose-binding lectin (MBL) is an important glycoprotein of the human innate immune system. Furthermore, individuals with sickle cell anemia (SCA) and MBL deficiency seem more susceptible to vaso-occlusive crises, suggesting an MBL role on HbSS red blood cells (RBCs). This study investigated the interaction of MBL with HbA (healthy) and HbSS RBCs using optical tweezers (OT) and atomic force microscopy (AFM).
View Article and Find Full Text PDFSmartphone-based non-invasive detection of salivary uric acid based on the fluorescence quenching of gleditsia sinensis carbon dots.
Mikrochim Acta
January 2025
Guizhou Province, Qianzhi Mingguang Soaphorn Rice Processing Base, Zhijin County, Maochang Town, Bijie CityBijie City, 552103, China.
A smartphone-based non-invasive method was developed for salivary uric acid detection using Gleditsia Sinensis carbon dots (GS-CDs). The GS-CDs synthesized by the one-pot hydrothermal method emitted blue fluorescence at a maximum excitation wavelength of 350 nm and had good fluorescence stability in the presence of different ions, while showing selectivity to uric acid solution. The ability of uric acid (UA) to quench the fluorescent substances present in the GS-CDs, was confirmed through HPLC-FLD and LC-MS, FTIR and XPS.
View Article and Find Full Text PDFFacile fabrication of biocompatible carbon dots from egg white by one-step neutralization heat reaction: a capillary array-based fluorimetric strategy for high-throughput detection of total iron ions in fish blood.
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January 2025
Huzhou Key Laboratory of Medical and Environmental Application Technologies, School of Life Sciences, Huzhou University, Huzhou 313000, China.
Water-soluble and biocompatible protein carbon dots (P-CDs) were simply prepared from egg white by a rapid one-step neutralization heat reaction. Unexpectedly, the thus-fabricated P-CDs could present excitation-dependent tunable fluorescence that could be quenched specifically by Fe and Fe ions with obvious color changes. A high-throughput fluorimetric platform was thereby developed by coating the P-CDs onto a capillary array for detection of total iron ions in fish blood samples, with a linear concentration range of 0.
View Article and Find Full Text PDFRecent advances on brain drug delivery via nanoparticles: alternative future materials for neuroscience applications; a review.
Rev Neurosci
January 2025
Neuroscience Research Center, Institute of Neuropharmacology, Kerman University of Medical Science, Kerman, Iran.
Essentially, the blood-brain barrier (BBB) serves as a line of demarcation between neural tissues and the bloodstream. A unique and protective characteristic of the blood-brain barrier is its ability to maintain cerebral homeostasis by regulating the flux of molecules and ions. The inability to uphold proper functioning in any of these constituents leads to the disruption of this specialized multicellular arrangement, consequently fostering neuroinflammation and neurodegeneration.
View Article and Find Full Text PDFA Review on the Applications of Quantum Dots in Sample Preparation.
J Sep Sci
January 2025
Department of Ocean Science, Iranian National Institute for Oceanography and Atmospheric Science, Tehran, Iran.
In recent years, despite significant advances in preconcentration and preparation techniques that have led to efficient recovery and accurate measurement of target compounds. There is still a need to develop adsorbents with unique and efficient features such as high pore volume and surface area, reactivity, easy synthesis, low toxicity, and compatibility with the environment, which increase the adsorption capacity and increase extraction efficiency. Semiconductor nanocrystals called quantum dots (QDs) with a size of less than 10 nm are three-dimensional nanoparticles with a spherical, rod, or disc structure that have significant potential in extraction as adsorbents due to their excellent properties such as low toxicity, reactivity, environmental friendliness, and hydrophilic and hydrophobic interactions.
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