Biopharmaceutical quality control with mass spectrometry.

Bioanalysis

School of Chemistry & Molecular Biosciences, The University of Queensland, St Lucia, QLD 4072, Australia.

Published: August 2021

Mass spectrometry (MS) is a powerful technique for protein identification, quantification and characterization that is widely applied in biochemical studies, and which can provide data on the quantity, structural integrity and post-translational modifications of proteins. It is therefore a versatile and widely used analytic tool for quality control of biopharmaceuticals, especially in quantifying host-cell protein impurities, identifying post-translation modifications and structural characterization of biopharmaceutical proteins. Here, we summarize recent advances in MS-based analyses of these key quality attributes of the biopharmaceutical development and manufacturing processes.

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Source
http://dx.doi.org/10.4155/bio-2021-0123DOI Listing

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