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Pharmacological activation of aldehyde dehydrogenase 2 inhibits ferroptosis via SLC7A11/GPX4 axis to reduce kidney stone formation.
Eur J Pharmacol
January 2025
Department of Urology, Tianjin Institute of Urology, The Second Hospital of Tianjin Medical University, Tianjin, China. Electronic address:
Calcium oxalate (CaOx) kidney stones pose a global health challenge due to their high prevalence and recurrence rates. While cell death mechanisms such as ferroptosis are known to play a crucial role in stone formation, the precise underlying mechanisms remain enigmatic. Aldehyde dehydrogenase 2 (ALDH2) is a metabolic enzyme of the ferroptosis product 4-hydroxy-2-nonenal (4-HNE).
View Article and Find Full Text PDF[Activation of ALDH2 alleviates hypoxic pulmonary hypertension in mice by upregulating the SIRT1/PGC-1α signaling pathway].
Nan Fang Yi Ke Da Xue Xue Bao
October 2024
Department of Cardiology, First Affiliated Hospital of Bengbu Medical University, Bengbu 233000, China.
Objective: To investigate whether activation of mitochondrial acetal dehydrogenase 2 (ALDH2) alleviates hypoxic pulmonary hypertension by regulating the SIRT1/PGC-1α signaling pathway.
Methods: Thirty 8-week-old C57 BL/6 mice were randomized into control, hypoxia, and hypoxia +Alda-1 (an ALDH2 activator) group (=10), and the mice in the latter two groups, along with 10 ALDH2 knockout (ALDH2) mice, were exposed to hypoxia (10% O, 90% N) with or without daily intraperitoneal injection of Alda-1 for 4 weeks. The changes in right ventricular function and pressure (RVSP) of the mice were evaluated by echocardiography and right ventricular catheter test, and pulmonary artery pressure was estimated based on RVSP.
Pharmacological activators of ALDH2: A new strategy for the treatment of alcohol use disorders.
Int Rev Neurobiol
November 2024
Department of Pharmacological and Toxicological Chemistry, Faculty of Chemical Sciences and Pharmacy, University of Chile, Santiago, Chile. Electronic address:
Article Synopsis
- * Despite its negative effects, acetaldehyde may also have rewarding properties in the brain, suggesting it plays a role in alcohol addiction.
- * The compound Alda-1 activates ALDH2, showing promise in animal studies for reducing alcohol consumption, preventing relapse, and protecting against alcohol-related tissue damage, indicating potential for treating alcohol use disorders.
Aldehyde dehydrogenase-2 deficiency aggravates neuroinflammation, nociception, and motor impairment in a mouse model of multiple sclerosis.
Free Radic Biol Med
November 2024
Laboratory of Pain and Signaling, Butantan Institute, São Paulo, SP, 05503-900, Brazil. Electronic address:
Aldehyde dehydrogenase-2 deficiency (ALDH2∗2) found in 36 % of Han Chinese, affects approximately 8 % of the world population. ALDH2 is a mitochondrial key enzyme in detoxifying reactive aldehydes to less reactive forms. Studies demonstrate a potential link between ALDH2∗2 mutation and neurodegenerative diseases.
View Article and Find Full Text PDFAlda-1 Ameliorates Oxidative Stress-Induced Cardiomyocyte Damage by Inhibiting the Mitochondrial ROS/TXNIP/NLRP3 Pathway.
J Biochem Mol Toxicol
November 2024
Department of Cardiology, Northern Jiangsu People's Hospital Affiliated to Yangzhou University, Yangzhou, Jiangsu, China.
Article Synopsis
- Alda-1 acts as an agonist of ALDH2 in mitochondria, helping maintain their structure and function.
- The study tested Alda-1's ability to reduce mitochondrial reactive oxygen species (mtROS) and protect heart cells (cardiomyocytes) from oxidative damage using hydrogen peroxide.
- Findings revealed that Alda-1 prevented mtROS buildup, reduced the harmful interactions that lead to cardiomyocyte damage, and showed that downregulating TXNIP further improved Alda-1's protective effects against oxidative stress.
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