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TREATMENT WITH SOLUBLE CD24 ATTENUATES COVID-19-ASSOCIATED SYSTEMIC IMMUNOPATHOLOGY. | LitMetric

AI Article Synopsis

  • SARS-CoV-2 triggers COVID-19 by damaging lung cells and causing systemic inflammation through the release of DAMPs, but CD24Fc shows potential in reducing this inflammatory response as shown in recent trials.
  • In a study with 22 patients from the SAC-COVID trial, researchers analyzed blood samples to assess the effects of CD24Fc compared to a placebo, revealing that CD24Fc helps restore immune balance without impairing antibody response against the virus.
  • Findings indicated that CD24Fc treatment significantly reduced inflammatory cytokine levels and normalized immune cell activity, suggesting it may be an effective therapy for severe COVID-19 patients.

Article Abstract

Background: SARS-CoV-2 causes COVID-19 through direct lysis of infected lung epithelial cells, which releases damage-associated molecular patterns (DAMPs) and induces a pro-inflammatory cytokine milieu causing systemic inflammation. Anti-viral and anti-inflammatory agents have shown limited therapeutic efficacy. Soluble CD24 (CD24Fc) is able to blunt the broad inflammatory response induced by DAMPs in multiple models. A recent randomized phase III trial evaluating the impact of CD24Fc in patients with severe COVID-19 demonstrated encouraging clinical efficacy.

Methods: We studied peripheral blood samples obtained from patients enrolled at a single institution in the SAC-COVID trial (NCT04317040) collected before and after treatment with CD24Fc or placebo. We performed high dimensional spectral flow cytometry analysis of peripheral blood mononuclear cells and measured the levels of a broad array of cytokines and chemokines. A systems analytical approach was used to discern the impact of CD24Fc treatment on immune homeostasis in patients with COVID-19.

Findings: Twenty-two patients were enrolled, and the clinical characteristics from the CD24Fc vs. placebo groups were matched. Using high-content spectral flow cytometry and network-level analysis, we found systemic hyper-activation of multiple cellular compartments in the placebo group, including CD8 T cells, CD4 T cells, and CD56 NK cells. By contrast, CD24Fc-treated patients demonstrated blunted systemic inflammation, with a return to homeostasis in both NK and T cells within days without compromising the ability of patients to mount an effective anti-Spike protein antibody response. A single dose of CD24Fc significantly attenuated induction of the systemic cytokine response, including expression of IL-10 and IL-15, and diminished the coexpression and network connectivity among extensive circulating inflammatory cytokines, the parameters associated with COVID-19 disease severity.

Interpretation: Our data demonstrates that CD24Fc treatment rapidly down-modulates systemic inflammation and restores immune homeostasis in SARS-CoV-2-infected individuals, supporting further development of CD24Fc as a novel therapeutic against severe COVID-19.

Funding: NIH.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8404902PMC
http://dx.doi.org/10.1101/2021.08.18.21262258DOI Listing

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