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IgD multiple myeloma with central nervous system involvement: A case report and literature review. | LitMetric

IgD multiple myeloma with central nervous system involvement: A case report and literature review.

Mol Clin Oncol

Fujian Provincial Key Laboratory on Haematology, Fujian Medical University Union Hospital, Fujian Institute of Haematology, Fuzhou, Fujian 350001, P.R. China.

Published: October 2021

Central nervous system (CNS) involvement is a rare manifestation of multiple myeloma (MM) and the optimal management strategies have yet to be determined. The aim of the present study was to describe the case of a 47-year-old male patient with immunoglobulin D-λ MM who presented with multiple extramedullary infiltrations at diagnosis. This patient achieved stringent complete response after 9 cycles of treatment with bortezomib, lenalidomide and dexamethasone, and then received lenalidomide as maintenance therapy. CNS involvement and extramedullary relapse developed 3 months after the last chemotherapy cycle. Despite receiving a second-line treatment protocol, the patient succumbed to the disease within 1 month after recurrence. The characteristics and treatment options for CNS MM are discussed in this case report.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8375031PMC
http://dx.doi.org/10.3892/mco.2021.2360DOI Listing

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