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[Aging nose (presbinasalis) in the practice of an otorhinolaryngologist.].
Adv Gerontol
June 2022
I.P.Pavlov First Saint-Petersburg State Medical University, 6-8 L. Tolstoy str., St. Petersburg 197022, Russian Federation, e-mail:
Population aging, increasing in duration of active life dictate to keep the level of health and create conditions for prolongation and preservation of ability to work. An otorhinolaryngologist often has to deal with age-related changes occurring in the nasal cavity and paranasal sinuses. The study of age-related features occurring in the nasal cavity and paranasal sinuses at the level of not only function, but also structures providing maintenance of mucous membrane protective mechanisms, preserving nasal architectonics, becomes a topical issue.
View Article and Find Full Text PDFAging-related olfactory loss is associated with olfactory stem cell transcriptional alterations in humans.
J Clin Invest
February 2022
Department of Head and Neck Surgery & Communication Sciences and.
Article Synopsis
- Presbyosmia, or age-related loss of smell, impacts many individuals over 65 and is linked to damage in the olfactory epithelium, though its mechanisms remain unclear and lack treatment options.
- The study utilized various methods, including biopsies and single-cell RNA sequencing, to investigate cellular changes in the olfactory epithelium of older adults, revealing inflammation-related alterations in stem cells that affect their ability to function properly.
- Findings suggest that these inflammatory changes in olfactory epithelium stem cells could be a key factor in the development of presbyosmia, indicating they may serve as a potential target for therapeutic interventions to restore sense of smell.
Olfactory loss and aging: connections with health and well-being.
Chem Senses
January 2021
Section of Otolaryngology-Head and Neck Surgery, Department of Surgery, The University of Chicago Medicine, Chicago, IL, USA.
Age-related olfactory dysfunction, or presbyosmia, is a common sensory impairment in aging adults. People in this demographic group with comorbid conditions or exposure to viral, traumatic, or environmental insults remain at the greatest risk for impairment. Several methods for assessing olfaction exist, but they are only available in special settings and require consideration of age, sex, ancestry, and cognition.
View Article and Find Full Text PDF[Aging and disorders of taste and smell].
Soins Gerontol
October 2020
Laboratoire de neurosciences intégratives et cliniques, EA 481, université de Bourgogne Franche-Comté, 19 rue Ambroise-Paré, 25030 Besançon cedex, France; Service de neurologie, centre hospitalier régional universitaire Jean-Minjoz, 3 boulevard Alexandre-Fleming, 25000 Besançon, France.
Compared with other sensory modalities, age-related alterations in taste and smell are less known and less investigated in clinical practice. In fact, the elderly with a loss of smell or taste may not always report it or be aware of it. In addition, the clinical evaluation of taste and smell by specific tests is rarely performed.
View Article and Find Full Text PDFDifferent patterns of age-related central olfactory decline in men and women as quantified by olfactory fMRI.
Oncotarget
October 2017
Department of Radiology, Center for NMR Research, The Pennsylvania State University College of Medicine, The Milton S. Hershey Medical Center, Hershey, PA, USA.
Age-related olfactory decline, or presbyosmia, is a prevalent condition with potentially devastating consequences on both quality of life and safety. Despite clear evidence for this decline, it is unknown whether presbyosmia is sex-dependent and also whether it is due to central or peripheral olfactory system deterioration. Therefore, the goals of this study were to investigate the neurofunctional substrate of olfactory decline and examine its relationship to age and sex in thirty-seven (18 women, 19 men) healthy older participants using olfactory functional MRI (fMRI).
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