AI Article Synopsis
- Osteochondral destruction and high recurrence rates post-surgery are significant challenges in treating tenosynovial giant cell tumors, prompting a study of 80 surgically treated patients with intra-articular tumors.
- The study found a 5-year local recurrence-free survival rate of 71.4%, with diffuse tumor type and knee location identified as key risk factors for recurrence and destruction.
- Additionally, local recurrence is associated with greater chances of osteochondral destruction, highlighting the importance of tumor type and location in managing these tumors.
Article Abstract
Osteochondral destruction and a high recurrence rate after surgery are major concerns that make difficult the treatment course of tenosynovial giant cell tumor. The aims of this study were to elucidate rates of postoperative local recurrence and osteochondral destruction, as correlated with various demographic factors. Eighty surgically treated patients with intra-articular tumors (knee: 49, ankle and foot: 12, hip: 10, others: 9) were included in this study. Factors including age, disease type (diffuse/localized), location, existence of osteochondral destruction were correlated with local recurrence or development/progression of osteochondral destruction. The 5-year local recurrence free survival rate was 71.4%. Diffuse type (n = 59, localized: n = 21) (P = 0.023) and knee location (P = 0.002) were independent risk factors for local recurrence. Diffuse type (P = 0.009) was a significant risk factor, and knee location (P = 0.001) was a negative factor for osteochondral destruction at the initial examination. Progression of osteochondral destruction was observed more often in cases with local recurrence (P = 0.040) and findings of osteochondral destruction at the initial examination (P = 0.029). Diffuse type is a factor that should be noted for both local recurrence and osteochondral destruction, while local recurrence occurs but osteochondral destruction is less observed in the knee.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8405684 | PMC |
| http://dx.doi.org/10.1038/s41598-021-96795-6 | DOI Listing |
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