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Canonical and noncanonical NOTCH signaling in the nongenetic resistance of cancer: distinct and concerted control.
Front Med
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Zhejiang University-University of Edinburgh Institute, School of Medicine, Zhejiang University, Jiaxing, 314400, China.
Therapeutic resistance in cancer is responsible for numerous cancer deaths in clinical practice. While target mutations are well recognized as the basis of genetic resistance to targeted therapy, nontarget mutation resistance (or nongenetic resistance) remains poorly characterized. Despite its complex and unintegrated mechanisms in the literature, nongenetic resistance is considered from our perspective to be a collective response of innate or acquired resistant subpopulations in heterogeneous tumors to therapy.
View Article and Find Full Text PDFPotential Health Risks from Heavy Metal in Green Mussels (Perna Viridis) From the Southeastern Part of the Bay of Bengal.
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January 2025
Department of Fisheries, Faculty of Marine Sciences and Fisheries, University of Chittagong, Chittagong, 4331, Bangladesh.
The Southeastern part of the Bay of Bengal is increasingly threatened by heavy metal pollution, posing significant risks to both aquatic life and human health. In this context, the contamination levels of six heavy metals-Cadmium (Cd), Lead (Pb), Zinc (Zn), Copper (Cu), Manganese (Mn), and Iron (Fe)-were assessed in the soft tissues of Green mussels (Perna viridis) from five key sites: Matamuhuri, Moheshkhali, Bakhkhali, Naf, and St. Martin.
View Article and Find Full Text PDFBrain modulatory effects of rehabilitation interventions in fibromyalgia: a systematic review of magnetic resonance imaging studies.
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International Ph.D. Program in Medicine, College of Medicine, Taipei Medical University, Taipei, 110, Taiwan.
Objectives: Fibromyalgia imposes a considerable burden of disability worldwide, and its therapies include rehabilitation interventions. However, the overall brain modulatory effects of rehabilitation interventions and their effects on clinical improvements in patients with fibromyalgia remain unclear. This systematic review of magnetic resonance imaging studies synthesised evidence for the brain modulatory effects of rehabilitation in patients with fibromyalgia.
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View Article and Find Full Text PDFWith the rise of internet and social media usage in the 21st century, patients have increasingly been looking to online resources for information regarding their health care. It is imperative for physicians to recognize the trends and role of these tools in clinical orthopaedic practice, and to harness these tools to educate users, connect with other physicians, and interact with current and potential patients. It is important to review the current literature regarding social media in orthopaedics; some commonly used social media platforms and their individual characteristics; and general guidelines for creating content and managing an online reputation.
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