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Immunotherapy response induces divergent tertiary lymphoid structure morphologies in hepatocellular carcinoma.
Nat Immunol
November 2024
Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Johns Hopkins University, Baltimore, MD, USA.
Tertiary lymphoid structures (TLS) are associated with improved response in solid tumors treated with immune checkpoint blockade, but understanding of the prognostic and predictive value of TLS and the circumstances of their resolution is incomplete. Here we show that in hepatocellular carcinoma treated with neoadjuvant immunotherapy, high intratumoral TLS density at the time of surgery is associated with pathologic response and improved relapse-free survival. In areas of tumor regression, we identify a noncanonical involuted morphology of TLS marked by dispersion of the B cell follicle, persistence of a T cell zone enriched for T cell-mature dendritic cell interactions and increased expression of T cell memory markers.
View Article and Find Full Text PDFSPONTANEOUS REGRESSION OF HEPATOCELLULAR CARCINOMA: FOCUSING IN THE ASSOCIATED RISK FACTORS.
Arq Gastroenterol
May 2024
Universidade Federal de Ciências da Saúde de Porto Alegre, Departamento de Clínica Médica, Porto Alegre, RS, Brasil.
Background: Spontaneous regression (SR) is defined as the partial or complete disappearance of a tumor, in the absence of a specific treatment. Evidence of the SR in hepatocellular carcinoma (HCC) is rare.
Objective: The authors aimed to review all the cases of SR of HCC in two reference centers of Southern Brazil, highlighting the main characteristics.
Immune landscape of tertiary lymphoid structures in hepatocellular carcinoma (HCC) treated with neoadjuvant immune checkpoint blockade.
bioRxiv
October 2023
Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Article Synopsis
- Neoadjuvant immunotherapy may help achieve long-term tumor remission by boosting the body's immune responses before tumor removal, and this study explores the role of tertiary lymphoid structures (TLS) in this process for liver cancer (HCC).
- The research found that neoadjuvant immunotherapy not only promotes the formation of TLS but also correlates with better treatment outcomes, including higher levels of T and B cells and improved disease-free survival.
- Notably, the study observed that as tumors regress, TLS undergo changes that indicate continued immune activity and contribute to T cell memory, which may be crucial for long-term immunity against cancer.
Post-castration prostatic involution: A morphometric and endocrine study of healthy canines and those with benign prostatic hyperplasia.
Reprod Domest Anim
February 2022
Unidad de Imagenología y Análisis Clínicos, Departamento de Clínicas y Hospital Veterinario, Facultad de Veterinaria, Universidad de la República, Montevideo, Uruguay.
The objective of this study was to evaluate the effect of castration on dimensions of the prostate by B-mode ultrasound for 90 days, as well as to evaluate changes in serum concentrations of testosterone and oestradiol in clinically healthy canines and those with benign prostatic hyperplasia (BPH). Three groups of animals were used: healthy canines castrated on day 0 (HCC, n = 8), canines with a diagnosis of benign prostatic hyperplasia (BPHC, n = 9) castrated on day 0 and healthy uncastrated canines (IHCC, n = 10). Prostate size was obtained by B-mode ultrasound, while blood samples were collected (days 0, 7, 14, 28, 60 and 90 post-castration) to determine the serum testosterone and oestradiol concentration.
View Article and Find Full Text PDFAblation Zone Involution of Liver Tumors Is Faster in Patients Treated with Irreversible Electroporation Than Microwave Ablation.
Medicina (Kaunas)
August 2021
Department of Mechanical & Industrial Engineering, University of Massachusetts, Amherst, MA 01002, USA.
: To compare ablation zone involution following microwave ablation (MWA) or irreversible electroporation (IRE) of liver tumors. : MWA or IRE performed for colorectal cancer liver metastasis (CRLM) or hepatocellular carcinoma (HCC) during January 2011 to December 2015 were analyzed. Patients with a tumoral response on 1-year follow-up computed tomography (CT) were included.
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