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| http://dx.doi.org/10.1097/HCR.0000000000000625 | DOI Listing |
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Nuclear Factor Erythroid 2-Related Factor 2 Activator DDO-1039 Ameliorates Podocyte Injury in Diabetic Kidney Disease via Suppressing Oxidative Stress, Inflammation, and Ferroptosis.
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National Clinical Research Center of Kidney Diseases, Jinling Hospital, Nanjing University School of Medicine, Nanjing, China.
Diabetic kidney disease (DKD) is the leading cause of end-stage kidney disease, and podocyte injury is one of the major contributors to DKD. As a crucial transcriptional factor that regulates cellular response to oxidative stress, nuclear factor erythroid 2-related factor 2 (Nrf2) is an attractive therapeutic target for DKD. In this study, we evaluated the therapeutic potential of DDO-1039, a novel small-molecule Nrf2 activator developed with protein-protein interaction strategy, on podocyte injury in DKD.
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Non-Communicable Diseases, Division, Indian Council of Medical Research, New Delhi, India.
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View Article and Find Full Text PDFThe Impact of HPV Vaccination on Cervical Cancer in adolescent females: A narrative review.
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View Article and Find Full Text PDFResidential and non-residential buildings are a major contributor to human well-being. At the same time, buildings cause 30% of final energy use, 18% of greenhouse gas emissions (GHGE), and about 65% of material accumulation globally. With electrification and higher energy efficiency of buildings, material-related emissions gain relevance.
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