AI Article Synopsis
- The study examined how lesions in the area postrema and selective vagotomy of afferent fibers affect nausea caused by emetine in rats.
- Rats were conditioned to avoid a 0.1% saccharin solution after being injected with emetine, with three groups being tested: one with afferent vagotomy, one with area postrema lesions, and a control group.
- Results showed that the control and vagotomy groups developed taste avoidance quickly, while the area postrema lesion group did not acquire any taste avoidance, highlighting the area postrema's critical role in nausea induction.
Article Abstract
We investigated the effect of area postrema lesions and selective vagotomy of afferent fibers on emetine-induced nausea in rats. We evaluated the acquisition of the conditioned taste avoidance (CTA) to 0.1% saccharin solution after conditioning with emetine dihydrochloride (5.54 mg/kg, i.p., 1% BW). The CTA was measured in three groups of rats: a bilateral subdiaphragmatic afferent vagotomy group, an area postrema lesion group, and a sham lesion group. The bilateral vagotomy and sham groups of rats showed acquisition of CTA within 2 days of the test date. Taste avoidance was never conditioned in the area postrema lesion group. These results indicate that the area postrema plays a crucial role in the induction of emetine-induced nausea.
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| http://dx.doi.org/10.1016/j.physbeh.2021.113565 | DOI Listing |
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