AI Article Synopsis
- Therapeutic genome modification currently struggles with precise control over gene expression, leading to inconsistent therapeutic results.
- Traditional gene and cell therapies often use semi-quantitative methods, limiting their ability to effectively manage timing and levels of gene expression.
- Synthetic biology presents innovative tools and approaches that can improve the design and functionality of therapeutic systems, with promising examples of engineered biomolecules and gene circuits in clinical applications.
Article Abstract
Therapeutic genome modification requires precise control over the introduced therapeutic functions. Current approaches of gene and cell therapy fail to deliver such command and rely on semi-quantitative methods with limited influence on timing, contextuality and levels of transgene expression, and hence on therapeutic function. Synthetic biology offers new opportunities for quantitative functionality in designing therapeutic systems and their components. Here, we discuss synthetic biology tools in their therapeutic context, with examples of proof-of-principle and clinical applications of engineered synthetic biomolecules and higher-order functional systems, i.e. gene circuits. We also present the prospects of future development towards advanced gene-circuit therapy.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8590856 | PMC |
| http://dx.doi.org/10.18388/abp.2020_5744 | DOI Listing |
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