The absolute configuration of rakicidin C was predicted by comparison of optical rotation data and absolute configuration of APD-cyclic depsipeptides and further determined by total synthesis. The absolute configuration of five chiral centers was determined as 2, 15, 16, 17, and 19. Our efficient route involves 19 longest linear steps with an overall yield of 1.49%.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1021/acs.orglett.1c02476 | DOI Listing |
Publication Analysis
Top Keywords
absolute configuration
16
total synthesis
8
configuration rakicidin
8
synthesis determination
4
absolute
4
determination absolute
4
configuration
4
rakicidin absolute
4
rakicidin predicted
4
predicted comparison
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!