AI Article Synopsis
- - Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the virus causing the COVID-19 pandemic, which has led to significant global economic issues.
- - To effectively develop vaccines and treatments, it’s crucial to understand the molecular interactions between the virus, host cells, and the immune system.
- - The review emphasizes the importance of chemical biology in studying these interactions, outlining established strategies and how they can improve our understanding of coronavirus-host interactions at a molecular level.
Article Abstract
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for the current coronavirus disease 2019 (COVID-19) pandemic that has led to a global economic disruption and collapse. With several ongoing efforts to develop vaccines and treatments for COVID-19, understanding the molecular interaction between the coronavirus, host cells, and the immune system is critical for effective therapeutic interventions. Greater insight into these mechanisms will require the contribution and combination of multiple scientific disciplines including the techniques and strategies that have been successfully deployed by chemical biology to tease apart complex biological pathways. We highlight in this review well-established strategies and methods to study coronavirus-host biophysical interactions and discuss the impact chemical biology will have on understanding these interactions at the molecular level.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8340996 | PMC |
| http://dx.doi.org/10.1039/d0cb00197j | DOI Listing |
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