Activation of the aryl hydrocarbon receptor (AHR) by endogenous ligands has been implicated in a variety of physiological processes such as cell cycle regulation, cell differentiation and immune responses. It is reported that tryptophan metabolites, such as kynurenine (Kyn) and 6-formylindolo(3,2-b)carbazole (FICZ), are endogenous ligands for AHR ( Stockinger , 2014 ). This protocol is designed for treatment with Kyn or FICZ in mouse embryonic fibroblasts (MEFs) or primary peripheral monocytes.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8376606 | PMC |
| http://dx.doi.org/10.21769/BioProtoc.2097 | DOI Listing |
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