AI Article Synopsis

  • Hepatitis is an inflammatory liver condition mainly caused by hepatitis B and C viruses and can lead to serious complications like cancer, posing a significant public health issue.
  • The study identified new genetic regions related to hepatitis infections through a meta-analysis of genetic data from both Asian and European populations.
  • Further analysis showed that certain genes connected to autophagy and immune responses are involved, highlighting their importance in understanding how hepatitis viruses affect the body.

Article Abstract

Hepatitis is an inflammatory condition of the liver, which is frequently caused by the infection of hepatitis B virus (HBV) or hepatitis C virus (HCV). Hepatitis can lead to the development of chronic complications including cancer, making it a major public health burden. Co-infection of HBV and HCV can result in faster disease progression. Therefore, it is important to identify shared genetic susceptibility loci for HBV and HCV infection to further understand the underlying mechanism. Through a meta-analysis based on genome-wide association summary statistics of HBV and HCV infection, we found one novel locus in the Asian population and two novel loci in the European population. By functional annotation based on multi-omics data, we identified the likely target genes at each novel locus, such as and , which play a critical role in autophagy and immune response to virus. By re-analyzing a microarray dataset from Hmgb1 mice and RNA-seq data from mouse liver tissue overexpressing , we found that differential expression of autophagy and immune and metabolic gene pathways underlie these conditions. Our study reveals novel common susceptibility loci to HBV and HCV infection, supporting their role in linking autophagy signaling and immune response.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8397444PMC
http://dx.doi.org/10.3389/fcell.2021.690882DOI Listing

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