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| http://dx.doi.org/10.1007/s40670-019-00741-1 | DOI Listing |
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Reactive oxygen species: Orchestrating the delicate dance of platelet life and death.
Redox Biol
January 2025
School of Basic Medical Sciences, Southwest Medical University, Luzhou, 646000, China; Key Laboratory of Medical Electrophysiology, Ministry of Education & Medical Electrophysiological Key Laboratory of Sichuan Province, (Collaborative Innovation Center for Prevention of Cardiovascular Diseases), Institute of Cardiovascular Research, Southwest Medical University, Luzhou, 646000, China. Electronic address:
Article Synopsis
- Platelets play a critical role in blood clotting and the immune response, relying on a balanced relationship between their production and destruction influenced by reactive oxygen species (ROS).
- Moderate levels of ROS enhance platelet production and function, aiding in processes like collagen binding and thrombus formation, but high levels can lead to platelet apoptosis and increased risk of thrombosis.
- The review emphasizes the need for further research into specific ROS signaling pathways, which could lead to new therapies for platelet-related disorders by leveraging the beneficial aspects of ROS while managing their harmful effects.
'Dancing with emotions': An Interpretive Descriptive study of facilitators recognition and response to students' emotions during simulation.
Med Educ
October 2024
Centre for Medical Education, Queen's University Belfast, Belfast, UK.
Introduction: Immersive simulations can evoke a range of emotions in students. However, little is known about how facilitators recognise and respond to students' emotions during simulations. This study aims to understand how simulation facilitators perceive and respond to students' emotions during simulation-in order to optimise learning.
View Article and Find Full Text PDFAnticoagulation in Chronic Kidney Disease.
Drugs
October 2024
Hospital Marina Salud, Denia, Alicante, Spain.
Article Synopsis
- The management of anticoagulation in chronic kidney disease (CKD) patients is complex due to increased risks of bleeding and clotting, necessitating careful dosing and monitoring.
- The introduction of direct oral anticoagulants (DOACs) offers potential benefits like easier management and reduced monitoring needs, yet their use in advanced CKD is still being explored.
- Innovative approaches like left atrial appendage occlusion (LAAO) could enhance treatment options for CKD patients at risk for stroke, but further research is needed to ensure their safety and efficacy.
Unveiling the dynamics of gut microbial interactions: a review of dietary impact and precision nutrition in gastrointestinal health.
Front Nutr
May 2024
Department of Haematology and Oncology, Shenzhen Children's Hospital, Shenzhen, China.
Article Synopsis
- The human microbiome is the community of tiny living things in our guts that affects our overall health, especially digestion.
- The review explains how what we eat influences our gut bacteria and how this connection also affects our emotions and brain health.
- New strategies, like special diets and personalized nutrition, are being developed to keep our gut healthy and help treat problems related to digestion.
Decoding the effect of photoperiodic cues in transducing kisspeptin-melatonin circuit during the pubertal onset in common carp.
Mol Reprod Dev
May 2024
TREE Lab, Department of Biomedical and Life Sciences, School of Science, Navrachana University, Vadodara, India.
This study unravels the intricate interplay between photoperiod, melatonin, and kisspeptin to orchestrate the pubertal onset of Common carp. Female fingerlings exposed to long days (LD) exhibited a hormonal crescendo, with upregulated hypothalamic-pituitary-ovarian (HPO) axis genes (kiss1, kiss1r, kiss2, gnrh2, gnrh3) and their downstream targets (lhr, fshr, ar1, esr1). However, the expression of the melatonin receptor (mtnr1a) diminished in LD, suggesting a potential inhibitory role.
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