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| http://dx.doi.org/10.4103/psychiatry.IndianJPsychiatry_320_20 | DOI Listing |
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Co-catalpol alleviates fluoxetine-induced main toxicity: Involvement of ATF3/FSP1 signaling-mediated inhibition of ferroptosis.
Phytomedicine
April 2024
College of Pharmacy, Henan University of Chinese Medicine, Zhengzhou, 450046, China.
Background: Fluoxetine is often used as a well-known first-line antidepressant. However, it is accompanied with hepatogenic injury as its main organ toxicity, thereby limiting its application despite its superior efficacy. Fluoxetine is commonly traditionally used combined with some Chinese antidepressant prescriptions containing Rehmannia glutinosa (Dihuang) for depression therapy and hepatoprotection.
View Article and Find Full Text PDFA Simple ICT-Based Fluorescent Probe for HOCl and Bioimaging Applications.
Biosensors (Basel)
July 2023
School of Pharmacy, Harbin University of Commerce, Harbin 150076, China.
Article Synopsis
- Drug-induced liver damage (DILI) has become a significant public health issue, with ClO identified as a potential biomarker for its detection.
- A new fluorescent probe was developed to detect ClO by modifying a dye, showing a low detection limit, rapid response, and effective tissue penetration.
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Protective role of ellagic acid and taurine against fluoxetine induced hepatotoxic effects on biochemical and oxidative stress parameters, histopathological changes, and gene expressions of IL-1β, NF-κB, and TNF-α in male Wistar rats.
Life Sci
September 2022
Department of Clinical Biochemistry, Fasa University of Medical Sciences, Fasa, Iran. Electronic address:
Purposes: Hepatic bioactivation of fluoxetine (FXN) could increase free radicals' generation provoking hepatotoxicity. Therefore, the protective effects of ellagic acid (EA) and taurine (TAU) treatments against fluoxetine-induced liver damage in rats were examined.
Materials And Methods: Sixty four male Wistar rats were randomly assigned to 8 groups (n = 8).
Baicalin provides protection against fluoxetine-induced hepatotoxicity by modulation of oxidative stress and inflammation.
World J Hepatol
April 2022
Department of Biochemistry, University of Allahabad, Prayagraj 211002, India.
Background: Fluoxetine is one of the most widely prescribed anti-depressant drugs belonging to the category of selective serotonin reuptake inhibitors. Long-term fluoxetine treatment results in hepatotoxicity. Baicalin, a natural compound obtained from the Chinese herb is known to have antioxidant, hepatoprotective and anti-inflammatory effects.
View Article and Find Full Text PDFFluoxetine-induced hepatic lipid accumulation is mediated by prostaglandin endoperoxide synthase 1 and is linked to elevated 15-deoxy-Δ PGJ.
J Appl Toxicol
June 2022
Department of Obstetrics and Gynecology, McMaster University, Hamilton, Ontario, Canada.
Major depressive disorder and other neuropsychiatric disorders are often managed with long-term use of antidepressant medication. Fluoxetine, an SSRI antidepressant, is widely used as a first-line treatment for neuropsychiatric disorders. However, fluoxetine has also been shown to increase the risk of metabolic diseases such as non-alcoholic fatty liver disease.
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