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Prognostic impact of coronary microvascular dysfunction assessed by AMR in acute coronary syndrome patients with chronic kidney disease.
Front Cardiovasc Med
January 2025
Department of Cardiology, Peking University China-Japan Friendship School of Clinical Medicine, Beijing, China.
Background: Angiography-derived microcirculatory resistance (AMR) is proposed as a novel, pressure- temperature-wire-free and less-invasive method to evaluate coronary microvascular dysfunction (CMD). This study aims to examine the prognostic role of CMD assessed by AMR in predicting adverse events in acute coronary syndrome (ACS) patients with chronic kidney disease (CKD).
Methods: This retrospective cohort study included ACS with CKD patients in the China-Japan Friendship Hospital from January 2016 to November 2022.
The association of capillary refill time and return of spontaneous circulation during out-of-hospital cardiac arrest: an observational study.
Crit Care
January 2025
Emergency Medical Service Vienna, Vienna, Austria.
Introduction: Microcirculatory alterations are predictive of poor outcomes in patients with shock and after cardiac arrest in animal models. However, microcirculatory alterations during human cardiac arrest have not yet been studied.
Methods: We prospectively included adult patients receiving resuscitation after witnessed out-of-hospital cardiac arrest.
The endothelium or mitochondrial level therapy: new frontiers in sepsis?
Med Intensiva (Engl Ed)
January 2025
Intensive Care Unit, Adesh Medical College and Hospital, NH44, Mohri, Ambala, Haryana-136135, India; Department of Anaesthesiology and Critical Care, Command Hospital (NC), Udhampur 182101, India. Electronic address:
Article Synopsis
- The host and microbes interact closely to regulate inflammation in sepsis, highlighting its complexity.
- Sepsis is increasingly viewed as a problem with the mitochondrial system, often linked to poor blood flow and oxygen supply ("microcirculatory and mitochondrial distress syndrome").
- Future treatments aimed at improving endothelial function or mitochondrial health could significantly reduce the severity and death rates associated with sepsis.
Functional coronary assessment in angina with intermediate coronary stenosis: the #FullPhysiology approach.
Eur Heart J
January 2025
Cardiology Unit, Azienda Ospedaliero Universitaria di Ferrara, Via Aldo Moro 8, 44124 Cona, Italy.
Early Microcirculatory Dysfunction on Perfusion CT Is Related to Prognosis After Aneurysmal Subarachnoid Hemorrhage.
Transl Stroke Res
January 2025
Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, No.119 South 4 Ring West Road, Beijing, 100070, Fengtai District, China.
Microcirculatory dysfunction is an important pathophysiology mechanism of early brain injury after aneurysmal subarachnoid hemorrhage (aSAH), which contributes to poor outcomes. The study was performed in Beijing Tiantan Hospital from October 2020 to July 2023. Patients with aSAH who underwent computed tomographic perfusion (CTP) within 24 h after ictus were enrolled prospectively.
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