: Cancer is the leading cause of death globally according to WHO in 2020. It is initiated by genetic mutations that occur due to numerous factors. : This review provides a clear view of the potential use of chromosome 6 open reading frame 106 () as a biomarker, based on previous studies. : Recent studies have investigated the association of C6orf106 with breast cancer and non-small cell lung cancer and showed that silencing leads to inhibition of malignancy in both diseases, as well as showing a positive correlation between C6orf106 expression and malignancy. Other studies demonstrated the interaction of C6orf106 with other malignancy factors that play a role in many cancer types, such as cyclin A2, cyclin B1, N-cadherin, E-cadherin, c-MYC, p120ctn, and vimentin. These factors play a significant role in cellular adhesion and the regulation of the cell cycle. is a potential target for numerous cancers, not only non-small cell lung cancer and breast cancer. : understanding the connection of with crucial malignancy factors makes it clear that is a potential therapeutic target and diagnostic biomarker for many disease cancer.
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