Duvelisib (DUV) is a is a small-molecule with inhibitory action for phosphoinositide 3-kinase (PI3K). It has been recently approved for the effective treatment of chronic lymphocytic leukemia (CLL) and small lymphocytic lymphoma (SLL). Novel charge transfer complex (CTC) between DUV, as electron donor, with chloranilic acid (CLA), as π electron acceptor has been synthesized and characterized using different spectroscopic and thermogravimetric techniques. UV-visible spectroscopy ascertained the formation of the CTC in different solvents of varying polarity indexes and dielectric constants via formation of new broad absorption band with maximum absorption peak (λ) in the range of 488-532 nm. The molar absorptivity of the CTC was dependent on the polarity index and dielectric constant of the solvent; the correlation coefficients were 0.9955 and 0.9749, respectively. The stoichiometric ratio of DUV:CLA was 1:1. Electronic spectral analysis was conducted for characterization of the complex in terms of its electronic constants. Computational calculation for atomic charges of energy minimized DUV was conducted and the site of interaction on DUV molecule was assigned. The solid-state CTC of DUV:CLA (1:1) was synthesized, and its structure was characterized by UV-visible, mass, FT-IR, and H NMR spectroscopic techniques. Both FT-IR and H NMR confirmed that both CT and hydrogen bonding contributed to the molecular composition of the complex. The reaction was adopted as a basis for developing a novel 96-microwell spectrophotometric assay (MW-SPA) for DUV. The assay limits of detection and quantitation were 0.57 and 1.72 µg/well, respectively. The assay was validated and all validation parameters were acceptable. The method was implemented successfully with great precision and accuracy to the analysis of the DUV in its bulk and capsules.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.saa.2021.120287 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
We report the cosolvency effect of formamidinium lead triiodide (FAPbI) in a mixture of γ-butyrolactone (GBL) and 2-methoxyethanol (2ME), a phenomenon where FAPbI shows higher solubility in the solvent blend than in either alone. We found that FAPbI exhibits 10× higher solubility in 30% 2ME in GBL than in 2ME alone and 40% higher solubility than in GBL alone at 90 °C. This enhanced solubility is attributed to the disruption of the hydrogen bonding network within 2ME, allowing its hydroxyl and ether groups to interact more freely with the solute.
View Article and Find Full Text PDFDevelopment of a Zeolitic Imidazolate Framework Based Superhydrophobic Surface with Abrasion Resistance, Corrosion Protection, and Anti-icing.
Langmuir
March 2025
Jiangxi Province Key Laboratory of Light Alloy, School of Advanced Manufacturing, Nanchang University, Nanchang 330031, P.R. China.
Herein, a superhydrophobic surface was designed and fabricated based on the "lotus effect" construction mechanism. The zeolitic imidazolate framework (ZIF-90) micro-nanoparticles were initially synthesized via a one-pot method, combined with long-chain stearic acid (STA), and subsequently embedded in polyvinyl butyral (PVB) to form a superhydrophobic surface at room temperature. The superhydrophobic surface demonstrated mechanical stability and retained its superhydrophobicity with a water contact angle (CA) greater than 150°, even at a wear distance of 400 cm.
View Article and Find Full Text PDFQuantum Well Superlattice Heteronanostructures for Efficient Photocatalytic Hydrogen Evolution.
ACS Nano
March 2025
State Key Laboratory of Applied Organic Chemistry, Key Laboratory of Nonferrous Metal Chemistry and Resources Utilization of Gansu Province, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, P. R. China.
In this study, we construct a quantum well effect-based two-dimensional Z-scheme superlattice heteronanostructure photocatalyst constructed from hydrogen-bonded porphyrin organic frameworks (HOFs) and carbon nitride. Porphyrin HOFs extend spectral absorption, while their π-conjugation and electron density variations significantly enhance charge separation and exhibit favorable alignment with the energy levels of carbon nitride, thereby enabling efficient charge transfer. Carboxylic acid channels in the HOFs further promote the decomposition of water molecules, thereby boosting hydrogen production.
View Article and Find Full Text PDFMoSe/BiSe Heterostructure Immobilized in N-Doped Carbon Nanosheets Assembled Flower-Like Microspheres for High-Rate Sodium Storage.
Small
March 2025
Key Laboratory of Colloid and Interface Chemistry, Ministry of Education, School of Chemistry and Chemical Engineering, Shandong University, Jinan, 250100, China.
A key challenge for sodium-ion batteries (SIBs) lies in identifying suitable host materials capable of accommodating large Na ions while addressing sluggish chemical kinetics. The unique interfacial effects of heterogeneous structures have emerged as a critical factor in accelerating charge transfer and enhancing reaction kinetics. Herein, MoSe/BiSe composites integrated with N-doped carbon nanosheets are synthesized, which spontaneously self-assemble into flower-like microspheres (MoSe/BiSe@N-C).
View Article and Find Full Text PDFA General Strategy for Exceptionally Robust Conducting Polymer-Based Bioelectrodes with Multimodal Capabilities Through Decoupled Charge Transport Mechanisms.
Adv Mater
March 2025
School of Chemical Engineering, Nanjing University of Science and Technology, Nanjing, 210094, P. R. China.
Bioelectrodes function as a critical interface for signal transduction between living organisms and electronics. Conducting polymers (CPs), particularly poly(3,4-ethylenedioxythiophene):poly(styrenesulfonate), are among the most promising materials for bioelectrodes, due to their electrical performance, high compactness, and ease of processing, but often suffer from degradation or de-doping even in some common environments (e.g.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!