Background: In patients undergoing transvenous lead extraction (TLE), lead dwell time has been recognized as a risk factor for extraction failure and procedure-related complications.
Objectives: The aim of this study was to evaluate the safety and effectiveness of TLE in patients with pacemaker or ICD leads with a dwell time of ≥20 years.
Methods: This is a single-center retrospective study of all patients who underwent TLE of at least 1 pacemaker or ICD leads a dwell time of ≥20 years.
Results: During the study period, 124 patients were included in this analysis (50.8% female, mean age: 74.6 ± 10.7 years). Device-related infection was the most common (92.7%) indication for TLE. Extraction was attempted for a total 313 leads, of which 182 leads had dwell times ≥20 years (median: 276 months; interquartile range: 255-300 months). Complete procedural success was achieved in 112/124 patients (90.3%), and clinical success in 119/124 patients (96.0%). Complete removal was achieved for 294 leads (93.9%), partial removal in 10 leads, and failure in 9 leads. Clinical success (combined complete and partial success) rates were higher for leads with dwell times <20 years compared to older leads (99.2% vs. 95.6%, p = .017). Major procedural complications (including 1 death) occurred in 7/124 patients (5.6%). Minor complications were observed in 8 patients (6.5%).
Conclusions: TLE of very old (≥20 years) leads can be performed with reasonable success and safety when conducted at centers with expertise in lead management.
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http://dx.doi.org/10.1111/jce.15229 | DOI Listing |
Diagnostics (Basel)
December 2024
Department of Medicine, Harbor-UCLA Medical Center, Torrance, CA 90502, USA.
Background: Lumen-apposing metal stents (LAMS) are utilized in a wide range of therapeutic gastrointestinal applications. We present our experience with LAMS-assisted drainage of complex pelvic abscesses at a large safety-net hospital.
Methods: EUS-guided LAMS placements for pelvic abscesses from July 2020 to June 2024 were analyzed.
Genetics
December 2024
Department of Life Science and Biotechnology, Jadavpur University, Kolkata 7000 32, India.
In Saccharomyces cerevisiae, SKS1 mRNA encoding a glucose-sensing serine/threonine kinase belongs to "nucleus-retained" (NR) mRNAs representing a subset of otherwise normal transcripts, which exhibits slow nuclear export and excessively long nuclear dwell time. Nuclear retention of the SKS1 mRNA triggered by a 202 nt "export-retarding" nuclear zip code (NZ) element promotes its rapid degradation in the nucleus by the nuclear exosome/CTEXT. In this investigation, we demonstrate that Dbp2p, an ATP-dependent DEAD-box RNA helicase binds to SKS1 and other NR-mRNAs and thereby inhibits their export by antagonizing with the binding of the export factors Mex67p/Yra1p.
View Article and Find Full Text PDFJ Cardiovasc Electrophysiol
January 2025
Heart Center, Department of Clinical and Experimental Cardiology, Amsterdam Cardiovascular Sciences, Amsterdam UMC, location AMC, The Netherlands.
The extravascular implantable cardioverter-defibrillator (EV-ICD) was developed to overcome complications associated with transvenous leads while being able to deliver anti-tachycardia pacing (ATP). The lead is implanted in the substernal space, which makes extraction a cautious procedure. We present a case of a 51-year-old women with a successful EV-ICD extraction after a lead dwell time of 4 years, which is the longest reported.
View Article and Find Full Text PDFEur J Clin Microbiol Infect Dis
December 2024
Nursing Department, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, 310000, China.
Background: Catheter-related bloodstream infection (CR-BSI) stands as one of the leading causes of hospital-acquired infections, often resulting in high healthcare expenditure and mortality rates. Despite efforts, reducing the incidence of CR-BSI remains a significant challenge.
Objective: This study aimed to assess the impact of a multidisciplinary organizational intervention on reducing intravenous CR-BSI.
Heart Rhythm
November 2024
Department of Medicine, Cardiology Division-Section of Electrophysiology, Emory University School of Medicine, Atlanta, Georgia, USA. Electronic address:
Background: Transvenous lead extraction (TLE) success and safety are heavily influenced by lead dwell time.
Objective: In this study, we aim to compare the clinical effectiveness and safety of TLE between young and old leads.
Methods: We retrospectively identified all TLE procedures at Emory Healthcare from 2007 to 2023.
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