Curated global climate data have been generated from climate model outputs for the last 120,000 years, whereas reconstructions going back even further have been lacking due to the high computational cost of climate simulations. Here, we present a statistically-derived global terrestrial climate dataset for every 1,000 years of the last 800,000 years. It is based on a set of linear regressions between 72 existing HadCM3 climate simulations of the last 120,000 years and external forcings consisting of CO, orbital parameters, and land type. The estimated climatologies were interpolated to 0.5° resolution and bias-corrected using present-day climate. The data compare well with the original HadCM3 simulations and with long-term proxy records. Our dataset includes monthly temperature, precipitation, cloud cover, and 17 bioclimatic variables. In addition, we derived net primary productivity and global biome distributions using the BIOME4 vegetation model. The data are a relevant source for different research areas, such as archaeology or ecology, to study the long-term effect of glacial-interglacial climate cycles for periods beyond the last 120,000 years.
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http://dx.doi.org/10.1038/s41597-021-01009-3 | DOI Listing |
Clin Chim Acta
January 2025
Department of Laboratory Medicine, Peking University Third Hospital, No. 49 Huayuan North Road, 100191, China; Institute of Medical Technology, Peking University Health Science Center, No. 38 Xueyuan Road, Beijing, 100191, China. Electronic address:
Although anthracyclines are important anticancer agents, their use is limited due to various adverse effects, particularly cardiac toxicity. Mechanisms underlying anthracycline-induced cardiotoxicity (AIC) are complex. Given the irreplaceable role of anthracyclines in treatment of malignancies and other serious diseases, early monitoring of AIC is paramount.
View Article and Find Full Text PDFCase Rep Surg
January 2020
Department of Pathology, Maulana Azad Medical College, New Delhi, India.
Unlabelled: . Omental cysts are a part of cystic lymphangiomas and are benign proliferations of ectopic lymphatics without a communication with the normal lymphatic system. They commonly involve the neck in the pediatric population and are uncommon at other sites and occur rarely in adults.
View Article and Find Full Text PDFJ Hered
August 2018
Department of Biological Sciences, University of Lethbridge, Lethbridge, AB, Canada.
The root of understanding speciation lies in determining the forces which drive it. In many closely-related species, including Sphyrapicus varius, S. nuchalis, and S.
View Article and Find Full Text PDFClin Sci (Lond)
April 2017
Centre for Pulmonary Hypertension, Thoraxclinic at the University Hospital Heidelberg, Röntgenstrasse 1, 69126 Heidelberg, Germany.
Heritable pulmonary arterial hypertension (HPAH) is an autosomal dominantly inherited disease caused by mutations in the () gene and/or genes of its signalling pathway in approximately 85% of patients. We clinically and genetically analysed an HPAH family without mutations in previously described pulmonary arterial hypertension (PAH) genes. Clinical assessment included electrocardiogram, lung function, blood gas analysis, chest X-ray, laboratory testing, echocardiography and right heart catheterization in case of suspected disease.
View Article and Find Full Text PDFFunct Plant Biol
August 2016
Research School of Biology, The Australian National University, Canberra, ACT 2601, Australia.
We measured a diverse range of foliar characteristics in shrub and tree species in temperate rainforest communities along a soil chronosequence (six sites from 8 to 120000 years) and used multilevel model analysis to attribute the proportion of variance for each trait into genetic (G, here meaning species-level), environmental (E) and residual error components. We hypothesised that differences in leaf traits would be driven primarily by changes in soil nutrient availability during ecosystem progression and retrogression. Several leaf structural, chemical and gas-exchange traits were more strongly driven by G than E effects.
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