Dexamethasone-loaded polymer hybrid nanoparticles were developed as a potential tool to treat alopecia areata due to their follicular targeting ability. Freeze drying (FD) is a common technique used to improve nanoparticle stability; however, there are few studies focused on its effect on ethyl cellulose lipid-core nanoparticles. Nanoparticles were lyophilized with different cryoprotectants. Sucrose was selected because it allowed for a good resuspension and provided acceptable physicochemical parameters (374.33 nm, +34.7 mV, polydispersion 0.229%, and 98.87% encapsulation efficiency). The nanoparticles obtained were loaded into a pleasant xanthan gum hydrogel, and the rheological, release, and skin permeation profiles of different formulations were studied. The FD formulation significantly modified the particle size, and the drug release and permeation properties were also altered. In addition, analyses of the cytotoxicity and anti-inflammatory efficacy of FD and non-FD particles on human keratinocytes indicated no differences.
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http://dx.doi.org/10.3390/pharmaceutics13081322 | DOI Listing |
Int J Pharm
December 2024
Evelo Biosciences, Cambridge, MA 02139, USA. Electronic address:
Interest in oral delivery of biological drug products, commonly prepared through lyophilization, is surging. Typically, low solid content solutions are employed for lyophilization to enhance mass transfer and minimize drying time. Yet, this approach often results in lyophilized powders with low bulk density and poor flowability, challenging downstream processing steps that are required for oral product development.
View Article and Find Full Text PDFAquat Toxicol
December 2024
School of Environmental Science & Engineering, Nanjing Tech University, 30 Puzhu Southern Road, Nanjing 211816, China. Electronic address:
The prevalence of microplastics (MPs) in aquatic environments has become the core of environmental pollution. In recent years, the inevitable biological aging process of MPs in natural environments has attracted researchers' attention. Such biofilm-mediated MPs, colonized by microorganisms, affect the physicochemical behavior and potential ecological risks of MPs.
View Article and Find Full Text PDFJ Pharm Sci
December 2024
Research and Development, AbbVie Inc., 1 North Waukegan Road, North Chicago, Illinois, 60064, United States.
Biopharmaceutical companies generate a wealth of data, ranging from in silico physicochemical properties and machine learning models to both low and high-throughput in vitro assays and in vivo studies. To effectively harnesses this extensive data, we introduce a statistical methodology facilitated by Accuracy, Utility, and Rank Order Assessment (AURA), which combines basic statistical analyses with dynamic data visualizations to evaluate endpoint effectiveness in predicting intestinal absorption. We demonstrated that various physicochemical properties uniquely influence intestinal absorption on a project-specific basis, considering factors like intestinal efflux, passive permeability, and clearance.
View Article and Find Full Text PDFPlant Foods Hum Nutr
December 2024
Program in Food Science and Technology, Department of Food Science and Technology, Federal University of Tocantins (UFT), Palmas, 77001-090, Brazil.
The black puçá (Mouriri pusa) is an unconventional fruit from the Cerrado region of Brazil, commonly known as the jabuticaba of the forest. However, data on its nutritional and phytochemical composition are limited. This study investigated the nutritional composition, physicochemical characteristics, profile of carbohydrates and organic acids, phenolics and flavonoids individual, amino acids composition, bioactive substances, and antioxidant potential in the pulp, peel, and seed fractions of puçá-preto.
View Article and Find Full Text PDFFront Immunol
December 2024
School of Basic Medicine, Guangzhou Medical University, Guangzhou, China.
Introduction: Borna disease virus 1 (BoDV-1) is an emerging zoonotic RNA virus that can cause severe acute encephalitis with high mortality. Currently, there are no effective countermeasures, and the potential risk of a future outbreak requires urgent attention. To address this challenge, the complete genome sequence of BoDV-1 was utilized, and immunoinformatics was applied to identify antigenic peptides suitable for vaccine development.
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