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Efficacy of Two Subcellular Vaccines in a Pregnant Ewe Challenge Model for Ovine Enzootic Abortion. | LitMetric

AI Article Synopsis

  • Enzootic abortion of ewes, caused by a specific pathogen, results in major reproductive losses for sheep farmers globally, leading to significant economic impacts.
  • The study compares two experimental vaccines (chlamydial outer membrane complex and octyl glucoside-COMC) against a commercial vaccine, revealing that both experimental vaccines prevented abortions and showed less bacterial shedding than the commercial option.
  • Results indicate that the COMC vaccine is the most effective and safest choice, but future research is needed to adjust the vaccine doses and inoculation frequency for better commercial use.

Article Abstract

, the aetiological agent of enzootic abortion of ewes, is a major cause of reproductive loss in small ruminants worldwide, accounting for significant economic losses to the farming industry. Disease can be managed through the use of commercial inactivated or live whole organism-based vaccines, although both have limitations particularly in terms of efficacy, safety and disease-associated outbreaks. Here we report a comparison of two experimental vaccines (chlamydial outer membrane complex (COMC) and octyl glucoside (OG)-COMC) based on detergent extracted outer membrane preparations of and delivered as prime-boost immunisations, with the commercial live vaccine Cevac Chlamydia in a pregnant sheep challenge model. No abortions occurred in either experimental vaccine group, while a single abortion occurred in the commercial vaccine group. Bacterial shedding, as a measure of potential risk of transmission of infection to naïve animals, was lowest in the COMC vaccinated group, with reductions of 87.5%, 86.4% and 74% observed for the COMC, OG-COMC and live commercial vaccine groups, respectively, compared to the unvaccinated challenge control group. The results show that the COMC vaccine performed the best and is a safer efficacious alternative to the commercial vaccines. However, to improve commercial viability, future studies should optimise the antigen dose and number of inoculations required.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8402522PMC
http://dx.doi.org/10.3390/vaccines9080898DOI Listing

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