RNA Phage VLP-Based Vaccine Platforms.

Pharmaceuticals (Basel)

Department of Molecular Genetics and Microbiology, University of New Mexico School of Medicine, Albuquerque, NM 87131, USA.

Published: August 2021

AI Article Synopsis

  • Virus-like particles (VLPs) derived from RNA bacteriophages are effective delivery systems for vaccine antigens that trigger strong immune responses.* -
  • The text discusses recent advancements in using RNA phage VLPs to present various antigens through different display techniques, including genetic, enzymatic, and chemical methods.* -
  • The focus is on how these VLPs can improve vaccine development by providing a more potent immune response.*

Article Abstract

Virus-like particles from a variety of RNA bacteriophages have turned out to be useful platforms for delivery of vaccine antigens in a highly immunogenic format. Here we update the current state of development of RNA phage VLPs as platforms for presentation of diverse antigens by genetic, enzymatic, and chemical display methods.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8401894PMC
http://dx.doi.org/10.3390/ph14080764DOI Listing

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