A Review and Evaluation of the Data Supporting Internal Use of .

is a Mediterranean plant with various pharmacological activities. Despite extensive reports on the bioactivity of the plant, its clinically studied applications have not yet been reviewed. The aim of our study was to gather information on the internal use of and its bioactive constituents to determine its efficacy and safety for human use. We reviewed research articles that have not been previously presented in this context and analyzed relevant clinical studies with . Cochranelibrary.com revealed six eligible clinical trials with that examined indications for pain management, cough, and mental exhaustion. Although the efficacy of has been demonstrated both in in vitro tests and in humans, it is difficult to attribute results from clinical trials to alone, as it has usually not been tested as the sole component. On the other hand, clinical trials provide positive information on the safety profile since no adverse effects have been reported. We conclude that is safe to use internally, while new clinical studies with as a single component are needed to prove its efficacy. Based on the recent trend in research, further studies are to be expected.