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| http://dx.doi.org/10.1093/ndt/gfab186 | DOI Listing |
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Person-Centered Web-Based Mobile Health System (Symptoms) for Reporting Symptoms in COVID-19 Vaccinated Individuals: Observational Study of System, Users, and Symptoms.
JMIR Form Res
October 2024
Department of Medical Sciences, Uppsala University, Uppsala, Sweden.
Article Synopsis
- The study investigates the side effects of COVID-19 vaccinations and infections, focusing on the benefits of self-reporting symptoms through a digital system called Symptoms.
- Researchers aimed to understand how this system can capture patient-reported outcomes, which vary in importance depending on individual needs.
- A total of 731 participants used the Symptoms system to track their health-related quality of life and symptoms, highlighting the relevance of personal experiences in monitoring vaccine side effects.
Patient engagement as a collaborative process in a large Dutch COVID-19 vaccination study (RECOVAC) - insight into the contribution of patient engagement and learnings for the future.
Res Involv Engagem
September 2024
Dutch Kidney Patients Association (NVN), Bussum, The Netherlands.
Background: The need for patient engagement in health research has been increasingly acknowledged and accepted in recent years. However, implementation is still limited due to lack of evidence on its value and lack of guidance on how to implement patient engagement. This study aims to provide insight into the contribution of patient engagement in the RECOVAC project, which studied COVID-19 vaccination in kidney patients, and formulate concrete practice-based action perspectives for patient engagement.
View Article and Find Full Text PDFRepeated COVID-19 Vaccination Drives Memory T- and B-cell Responses in Kidney Transplant Recipients: Results From a Multicenter Randomized Controlled Trial.
Transplantation
June 2024
Department of Internal Medicine, Nephrology and Transplantation, Erasmus MC Transplant Institute, Erasmus University Medical Center, Rotterdam, the Netherlands.
Background: Insight into cellular immune responses to COVID-19 vaccinations is crucial for optimizing booster programs in kidney transplant recipients (KTRs).
Methods: In an immunologic substudy of a multicenter randomized controlled trial (NCT05030974) investigating different repeated vaccination strategies in KTR who showed poor serological responses after 2 or 3 doses of an messenger RNA (mRNA)-based vaccine, we compared SARS-CoV-2-specific interleukin-21 memory T-cell and B-cell responses by enzyme-linked immunosorbent spot (ELISpot) assays and serum IgG antibody levels. Patients were randomized to receive: a single dose of mRNA-1273 (100 μg, n = 25), a double dose of mRNA-1273 (2 × 100 μg, n = 25), or a single dose of adenovirus type 26 encoding the SARS-CoV-2 spike glycoprotein (Ad26.
SARS-CoV-2-specific immune responses converge in kidney disease patients and controls with hybrid immunity.
NPJ Vaccines
May 2024
Department of Viroscience, Erasmus Medical Center, Rotterdam, The Netherlands.
Healthy individuals with hybrid immunity, due to a SARS-CoV-2 infection prior to first vaccination, have stronger immune responses compared to those who were exclusively vaccinated. However, little is known about the characteristics of antibody, B- and T-cell responses in kidney disease patients with hybrid immunity. Here, we explored differences between kidney disease patients and controls with hybrid immunity after asymptomatic or mild coronavirus disease-2019 (COVID-19).
View Article and Find Full Text PDFPost COVID-19 condition imposes significant burden in patients with advanced chronic kidney disease: A nested case-control study.
Int J Infect Dis
May 2024
Department of Internal Medicine, Division of Nephrology, Maastricht University Medical Center, Maastricht, The Netherlands; CARIM School for Cardiovascular Diseases, University of Maastricht, Maastricht, The Netherlands.
Background: The burden of post COVID-19 condition (PCC) is not well studied in patients with advanced kidney disease.
Methods: A large prospective cohort of SARS-CoV-2 vaccinated patients with chronic kidney disease stages G4-G5 (CKD G4/5), on dialysis, and kidney transplant recipients (KTR) were included. Antibody levels were determined after vaccination.
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