An intimate encounter: DC3s empower anti-tumor CTLs.

Cancer Cell

Department of Immunobiochemistry, Mannheim Institute for Innate Immunosciences (MI3) and European Center for Angioscience (ECAS), Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany. Electronic address:

Published: September 2021

Discrete tissue niches are emerging as essential prerequisites enabling cell communication and function in both homeostasis and disease. In a recent Cell paper, Di Pilato et al. identify a unique dendritic cell-cytotoxic T cell crosstalk within the perivascular space that facilitates T cell survival and proliferation and drives anti-tumor activity.

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http://dx.doi.org/10.1016/j.ccell.2021.08.010DOI Listing

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