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Decoding the blueprint of receptor binding by filoviruses through large-scale binding assays and machine learning.
Cell Host Microbe
January 2025
Department of Pathology, Microbiology, and Immunology, School of Veterinary Medicine, University of California, Davis, CA 95616, USA. Electronic address:
Evidence suggests that bats are important hosts of filoviruses, yet the specific species involved remain largely unidentified. Niemann-Pick C1 (NPC1) is an essential entry receptor, with amino acid variations influencing viral susceptibility and species-specific tropism. Herein, we conducted combinatorial binding studies with seven filovirus glycoproteins (GPs) and NPC1 orthologs from 81 bat species.
View Article and Find Full Text PDFTransformation processes of total suspended solids and dissolved organic matter in rivers: Influences of different land use sources and degradation processes.
Sci Total Environ
January 2025
China National Environmental Monitoring Centre, Beijing 100012, China.
The riverine dissolved organic matter (DOM) pool constitutes the largest and most dynamic organic carbon reservoir within inland aquatic systems. Human activities significantly alter the distribution of organic matter (OM) in rivers, thereby affecting the availability of DOM. However, the impact of total suspended solids (TSS) on DOM under anthropogenic influence remains insufficiently elucidated.
View Article and Find Full Text PDFPrescribed burning effects on carbon and nutrient cycling processes in peatlands of Greater Khingan Mountains, Northeast China.
Sci Total Environ
January 2025
State Key Laboratory of Black Soils Conservation and Utilization, Northeast Institute of Geography and Agroecology, Chinese Academy of Sciences, Shengbei Street 4888, 130102 Changchun, China; Key Laboratory of Wetland Ecology and Environment, Northeast Institute of Geography and Agroecology, Chinese Academy of Sciences, Shengbei Street 4888, 130102 Changchun, China. Electronic address:
Peatlands are significant global carbon sinks; however, their carbon storage functions are vulnerable to human activities. In the Greater Khingan Mountains of Northeast China, where forest and peatland ecosystems are interspersed extensively, prescribed burning is conducted annually on peatlands to prevent major forest fires. To investigate the effect of prescribed burning on carbon and nutrient cycling processes in peatlands, we conducted a three-year experiment in the Greater Khingan Mountains.
View Article and Find Full Text PDFGlobal impacts of land use on terrestrial carbon emissions since 1850.
Sci Total Environ
January 2025
State Key Laboratory of Environmental Geochemistry, Institute of Geochemistry, Chinese Academy of Sciences, Guiyang 550081, China.
Since the Industrial Revolution, significant changes in global land-use patterns have occurred, which have disrupted terrestrial carbon emissions. However, the disturbance processes, change trends, and distribution patterns are not clear. Therefore, the changes in terrestrial carbon emissions (E) caused by land-use change (LUC) since 1850 were analyzed in this study.
View Article and Find Full Text PDFGenetic variation of the circumsporozoite protein in parasite isolates from Homabay County in Kenya.
Front Parasitol
April 2024
Centre for Malaria Elimination, Institute of Tropical Medicine, Mount Kenya University, Thika, Kenya.
The Circumsporozoite Protein (PfCSP) has been used in developing the RTS,S, and R21 malaria vaccines. However, genetic polymorphisms within compromise the effectiveness of the vaccine. Thus, it is essential to continuously assess the genetic diversity of , especially when deploying it across different geographical regions.
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