Our perception of compliance is informed by multi-dimensional tactile cues. Compared with stationary cues at terminal contact, time-dependent cues may afford optimal efficiency, speed, and fidelity. In this work, we investigate strategies by which temporal cues may encode compliances by modulating our exploration time. Two potential perceptual strategies are considered, inspired by memory representations within and between explorations. For either strategy, we introduce a unique computational approach. First, a curve similarity analysis, of accumulating touch force between sequentially explored compliances, generates a minimum time for discrimination. Second, a Kalman filtering approach derives a recognition time from progressive integration of stiffness estimates over time within a single exploration. Human-subjects experiments are conducted for both single finger touch and pinch grasp. The results indicate that for either strategy, by employing a more natural pinch grasp, time-dependent cues afford greater efficiency by reducing the exploration time, especially for harder objects. Moreover, compared to single finger touch, pinch grasp improves discrimination rates in judging plum ripeness. The time-dependent strategies as defined here appear promising, and may tie with the time-scales over which we make perceptual judgments.
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http://dx.doi.org/10.1109/haptics45997.2020.ras.hap20.7.ec43f6a7 | DOI Listing |
Prog Neuropsychopharmacol Biol Psychiatry
January 2025
Department of Pharmacology, Federal University of Parana, Curitiba, Parana, Brazil. Electronic address:
Fear generalization, a lack of discrimination between safe and unsafe cues, is a hallmark of posttraumatic stress disorder. The phosphodiesterase 5 (PDE5) regulates the cyclic guanosine monophosphate (cGMP) pathway, which has been proposed to be involved in fear memory generalization. However, whether PDE5 activity underlies fear memory generalization remains unexplored.
View Article and Find Full Text PDFMem Cognit
December 2024
Department of Psychology, University of Zürich, Zurich, Switzerland.
Refreshing is assumed to reactivate the contents of working memory in an attention-based way, resulting in a boost of the attended representations and hence improving their subsequent memory. Here, we examined whether the refreshing-induced memory boost is a constant or a gradual, time-dependent phenomenon. If the beneficial effect of refreshing on memory performance is due to the information being selected for refreshing (i.
View Article and Find Full Text PDFDevelopment
December 2024
Great Ormond Street Institute of Child Health, University College London, London WC1N 1EH, UK.
Progenitor cells initiate development upon receiving key signals, dynamically altering gene and protein expression to diverge into various lineages and fates. Despite the use of several experimental approaches, including the Fluorescent Timer-based method Timer-of-cell-kinetics-and-activity (Tocky), analysing time-dependent processes at the single-cell level in vivo remains challenging. This study introduces a novel integrated experimental and computational approach, using an advanced multidimensional toolkit.
View Article and Find Full Text PDFMicron
February 2025
Institute of Biology, Biotechnology and Environmental Protection, Faculty of Natural Sciences, University of Silesia in Katowice, Bankowa 9, Katowice 40-007, Poland. Electronic address:
Organisms actively respond to shifts in their environment, and these responses are evident even among microinvertebrates like tardigrades. Encystment, regarded as a form of diapause, exemplifies a tardigrade's response to environmental change. Environmental cues and unidentified internal factors regulate this process in tardigrades.
View Article and Find Full Text PDFPhytomedicine
December 2024
Institute of Molecular Rhythm and Metabolism, School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangzhou, China. Electronic address:
Background: Aristolochic acid I (AAI), an emerging biogenic contaminant widely present in Aristolochic plants, has been implicated in the progression of tubulointerstitial disease, known as aristolochic acid nephropathy (AAN). The circadian clock, a vital regulator of organ homeostasis, is susceptible to external chemical cues, including toxins. However, the reciprocal interactions between AAI and the circadian clock remain unexplored.
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