Antithrombotic property of an aqueous extract from and .

Res Pharm Sci

Department of Pharmacology and Toxicology, Faculty of Pharmaceutical Sciences, Madonna University, River State, Nigeria.

Published: August 2021

Background And Purpose: An aqueous extract from the root bark of and aerial parts of has been proven in previous research to elicit significant anticoagulant property . This, therefore, indicates the potential usefulness of this extract in managing thromboembolic disease, a major global health risk. The aim of the present work was to establish the antithrombotic effect of a product made from extracts of the root bark of and the aerial parts of (PAE).

Experimental Approach: The effect of PAE at 500-2000 mg/kg in inhibiting tail infarction and inflammation, as well as its effect on the microthrombi count, hematological, and coagulation profiles in a carrageenan-induced thrombosis model in Sprague-Dawley rats, was studied.

Findings/results: PAE significantly ( ≤ 0.01-0.001) reduced length of tail infarction and inflammation (redness, swelling, pain, and temperature). Histopathological studies revealed a significant reduction ( ≤ 0.0001) in microthrombi count in the liver and the lungs with PAE treatment. PAE treatment caused a marginal ( ≤ 0.01) increase in prothrombin time but resulted in a significant ( ≤ 0.01-0.0001) dose-dependent increase in activated partial thromboplastin time, with the hematological profile being normal.

Conclusion And Implications: PAE showed anticoagulant and antithrombotic effects , indicative of its potential benefit as a natural product, and cost-effective therapeutic option, and hence could be helpful in thromboembolic therapies.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8356714PMC
http://dx.doi.org/10.4103/1735-5362.319581DOI Listing

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