AI Article Synopsis

  • The solute carrier (SLC) superfamily is the largest group of transporters, which play crucial roles in both health and disease, but many remain poorly studied due to a lack of research tools.
  • A primary obstacle in SLC research is the absence of effective cell-based assays and the scattered information on suitable assay strategies.
  • The RESOLUTE consortium, part of the Innovative Medicines Initiative, aims to enhance SLC research by offering high-quality tools and data, ultimately making SLCs more accessible for drug discovery.

Article Abstract

The solute carrier (SLC) superfamily represents the biggest family of transporters with important roles in health and disease. Despite being attractive and druggable targets, the majority of SLCs remains understudied. One major hurdle in research on SLCs is the lack of tools, such as cell-based assays to investigate their biological role and for drug discovery. Another challenge is the disperse and anecdotal information on assay strategies that are suitable for SLCs. This review provides a comprehensive overview of state-of-the-art cellular assay technologies for SLC research and discusses relevant SLC characteristics enabling the choice of an optimal assay technology. The Innovative Medicines Initiative consortium RESOLUTE intends to accelerate research on SLCs by providing the scientific community with high-quality reagents, assay technologies and data sets, and to ultimately unlock SLCs for drug discovery.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8383457PMC
http://dx.doi.org/10.3389/fphar.2021.722889DOI Listing

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